ID R0JEK2_ANAPL Unreviewed; 783 AA.
AC R0JEK2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
DE Flags: Fragment;
GN ORFNames=Anapl_04228 {ECO:0000313|EMBL:EOA95695.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOA95695.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; KB744204; EOA95695.1; -; Genomic_DNA.
DR AlphaFoldDB; R0JEK2; -.
DR HOGENOM; CLU_007149_2_0_1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044554; APC2-like.
DR InterPro; IPR014786; APC2_C.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR Pfam; PF08672; ANAPC2; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01013; APC2; 1.
DR SMART; SM00182; CULLIN; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 463..661
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 156..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOA95695.1"
FT NON_TER 783
FT /evidence="ECO:0000313|EMBL:EOA95695.1"
SQ SEQUENCE 783 AA; 90222 MW; 74F8C66A758BFB82 CRC64;
AAPRSDPVGP LKDADLRAAL EVLRCYDLHS IVEEWFIEVL QTDLQANIAP EFWNCIGQYE
NTAEEPQCSS LLLDAFCLLK CRLDPYLNSL ELLERWTKAG LLLGTGAQML QEKVYTMFKA
ILFFSTTKSF QEMIQQFYSR TFRIYMRQWK KGEEGMNECE SSMSENEQES DTEEGGGESQ
VCAGCGSKRE QCWCPKAMEQ FQQLNDILRR LNLLERVSAD AVTTILHRMI EERMEQRCRG
EYEHSFLNEF QEWIEKVIGW LSRVFLQDGP LARSSPEASS TLKRWRCHVQ RFFYRIYASM
RIEELFSIIR DFPESKPAVE DLKFCLERTN QRQQLLSSLK SALEMRLLHP GVNTSDIITL
YISAIKALRE LDPSMVILEV ACEPIRKYLR TREDTVRQIV AGLTGDAEGS GDLANELSKA
DPVTLENGQE SDDDISEPGD WVPDPVDADP GKSSSKRRSS DIISLLVSIY GSKDLFINEY
RTLLADRLLH QFNYSAEREI RNVELLKLRF GEAQMHYCEV MLKDMADSRR INANIRDEEE
KLPEEERPPF SLVAVILSSE FWPPLKEEKL ELPEQVKEAM EAYSKKYEKL KAMRTLNWKY
HLGLVNLDVE LADRTLSLSV SPVHAAIILH FQTKSTWTLT ELSEVLKVPV TSLKRKMTLW
LQQGVLREEP PGTFTVIEEE QKDQVEKVVL IDSDEEGDSA MASQADQKEE ELQLFWTYIQ
AMLTNLESLS LERIHSMLKM FVMTGPVVTE IDTQELQGFL QKKVRDQQLI YSGGVYRLPK
NCN
//
