ID   R0JZB4_ANAPL            Unreviewed;       357 AA.
AC   R0JZB4;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Lysosomal acid lipase/cholesteryl ester hydrolase {ECO:0000313|EMBL:EOB02961.1};
DE   Flags: Fragment;
GN   ORFNames=Anapl_05338 {ECO:0000313|EMBL:EOB02961.1};
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB02961.1, ECO:0000313|Proteomes:UP000296049};
RN   [1] {ECO:0000313|Proteomes:UP000296049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23749191; DOI=10.1038/ng.2657;
RA   Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA   Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA   Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA   Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA   Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA   Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA   Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA   Rao M., Pitel F., Wang J., Li N.;
RT   "The duck genome and transcriptome provide insight into an avian influenza
RT   virus reservoir species.";
RL   Nat. Genet. 45:776-783(2013).
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000256|ARBA:ARBA00010701}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB742907; EOB02961.1; -; Genomic_DNA.
DR   AlphaFoldDB; R0JZB4; -.
DR   Proteomes; UP000296049; Unassembled WGS sequence.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR006693; AB_hydrolase_lipase.
DR   InterPro; IPR025483; Lipase_euk.
DR   PANTHER; PTHR11005:SF168; LIPASE; 1.
DR   PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR   Pfam; PF04083; Abhydro_lipase; 1.
DR   PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:EOB02961.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000296049}.
FT   DOMAIN          2..60
FT                   /note="Partial AB-hydrolase lipase"
FT                   /evidence="ECO:0000259|Pfam:PF04083"
FT   ACT_SITE        135
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT   ACT_SITE        303
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT   ACT_SITE        332
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EOB02961.1"
FT   NON_TER         357
FT                   /evidence="ECO:0000313|EMBL:EOB02961.1"
SQ   SEQUENCE   357 AA;  41312 MW;  99445EC094639BA6 CRC64;
     GEIVRYHGYP YEEHEIVTDD GYYLTIQRIP HGRDNSGTPK PAVLLQHGLV LEGSNWVTNL
     PNSSLGFILA DAGYDVWIGN SRGNSWSRKH KEFEYHNEKY SAYSFHEMAM YDLPATINYI
     LRKTGQEQLY YVAYSQGTTT GFIAFSSIPE LDRKIKMFFA LAPITTSSNM KSPLVRVFDL
     PESLVKFILG HILVFDKGEI LQQVTSRLCG YTFFKSFCSL VLYLPGGFTD SLNVSRVDVY
     LSRYPDSTSV KNMLHWRQLY QTGEFKYYDY GSDNVLHYNQ STPPFYELEN MKAPLAAWYG
     GKDWISAPED VNITLPRITN MVYKKYIPEF VHFDFLWGMQ AYEHVYKEIL ELMKKNA
//