ID R0K1R7_ANAPL Unreviewed; 1523 AA.
AC R0K1R7;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Brain-specific angiogenesis inhibitor 1 {ECO:0000313|EMBL:EOB03871.1};
DE Flags: Fragment;
GN ORFNames=Anapl_14807 {ECO:0000313|EMBL:EOB03871.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB03871.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB742828; EOB03871.1; -; Genomic_DNA.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR CDD; cd15990; 7tmB2_BAI1; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR12011:SF39; ADHESION G PROTEIN-COUPLED RECEPTOR B1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 5.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 893..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 962..980
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1001..1020
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1040..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1084..1106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 520..590
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 896..1137
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 276..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1359..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1444..1468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOB03871.1"
FT NON_TER 1523
FT /evidence="ECO:0000313|EMBL:EOB03871.1"
SQ SEQUENCE 1523 AA; 170240 MW; DE7B1169899015EB CRC64;
CTTLVQGKFF GYFSSFAVFP LNSSLCSWII QNPDPRRYTL YMKILKPTGV CDHQHIRTYQ
FDSFLESTRT YLGMESFDDV LKLCDGSTRY AFLQSNKQFL QMKQTAPPGV ENGPVRWKPM
KAQERDFSVE YLVVGNRNPS KAACQMLCKW LDACLAISSS SHPCGIMQTP CSCSGGEVLD
QASEILGLAK KKEDCYKDGI YLENCMSSPK DSSGVEFMGG WNSWSAWGDC TKDCGGGLQT
RMRSCKPLPN EGLACEGVLE EGRLCNRKAC NTNGRYNSRS QSLRSTDNRK REDTDELQHY
GYPAPQIGDP AAEEWSPWSV CSTTCGEGWQ TRTRFCVSSS YSTQCSGPLR EQRQCNNSAV
CPVHGTWDEW SPWSLCSSTC GRGYRDRTRT CKPPQFGGNP CEGPEKQTKF CNIALCPVDG
NWNEWSSWSS CSASCSNGTQ QRTRECNGPS YGGAECQGHW VETRDCFLRQ CPVDGKWQAW
GVWGSCTTTC GGGTQRRDRV CYGPFFGGES CQGPKEEYKQ CNDRRCPEPH EICDEESLAS
VVWKETPAGD AAAVRCPRNA TGLILRRCTL DEEGIAYWEP PTYVKCVSID YRNIQMLTRE
HLSKAQRGLM VDGLSEVIQN LVEISQDGTS YSGDLLSTID VLRNMTEIFR RAYHSPTSGD
VQNFVQIISN LLSEENREKW EEAQLIGPNA KELFRLVEDF IDVIGFRMKD FRDSYQVTDN
LVLGIHKLPA NAATDITFPM KGWRGMVDWA KNSEDKVTVS KSILSSGLAE ADDSSVFVVG
TVLYRNVGNI LSLQRNSTVL NSKVISVTVK PFPRSLLTPL EIEFSHLYNG TTNQTCILWD
ENEGVSPTFP WCWVCVASQS TMEIRTASES PCVCVFAFCF NVLLSLFQNM EKVLVPSVTL
IVGCGVSSLT LLLLIIIYVS VWRYIRSERS VILINFCLSI ISSNALILIG QTQTRNKVIC
TLVAAFLHFF FLSSFCWVLT EAWQSYMAVT GRLRNRIIRK RFLCLGWGLP ALVVAISVGF
TKAKGYGTAN YCWLSLEGGL LYAFVGPAAA VVLVNMVIGI LVFNKLVSKD GITDKKLKER
AGASLWSSCV VLPLLALTWM SAVLAITDRR SALFQILFAV FDSLEGFVIV MVHCILRREV
QDAVKCRVVD RQEEGNGDSG GSFQNGHAQL MTDFEKDVDM ACRSVLNKDI TACRTSTITG
TLKRPSLQDE EKLKLNHQKG SSNFNSLPAN VSKMHLQGSP HYLGAINLNE FSNHSLTLKK
DKNQPPKSIY ICDGDIFKKL DSELSRAQEQ TLDTSYVILP TNTSTLRAKP PKDESKYSIN
IDQMPQTRLI HLSMATDPGF VVKSPPREPV TMTCSEVQGS SMIQQQQQLP PQNISNESQI
PNSLCDTGDS GNSGVVSKSE TVSTLSMSSL ERRKSRYAEL DFEKIMHTRK RHQDMFQDLN
RKLQHAEKEK ESPTTDSKQE KQQTPNKRPW EGIRKVQSPP SWVKKDIEPV AQSPLELKTV
EWEKTGATIP LVGQDIIDLQ TEV
//
