ID R0K5Y4_ANAPL Unreviewed; 3343 AA.
AC R0K5Y4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Breast cancer type 2 susceptibility protein {ECO:0000313|EMBL:EOB05566.1};
DE Flags: Fragment;
GN ORFNames=Anapl_06922 {ECO:0000313|EMBL:EOB05566.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB05566.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
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DR EMBL; KB742680; EOB05566.1; -; Genomic_DNA.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR CDD; cd04494; BRCA2DBD_OB2; 1.
DR CDD; cd04495; BRCA2DBD_OB3; 1.
DR Gene3D; 6.10.70.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 4.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR048262; BRCA2_OB_2_dom.
DR InterPro; IPR015188; BRCA2_OB_3.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF09104; BRCA-2_OB3; 1.
DR Pfam; PF00634; BRCA2; 5.
DR Pfam; PF21318; BRCA2DBD_OB2; 1.
DR Pfam; PF09121; Tower; 1.
DR PIRSF; PIRSF002397; BRCA2; 2.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 6.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2763..2804
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 287..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1383..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1427..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1863..1884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2309..2341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3159..3181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3215..3238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3276..3343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2777..2804
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 287..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1383..1397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2322..2336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3221..3238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3284..3299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3329..3343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOB05566.1"
FT NON_TER 3343
FT /evidence="ECO:0000313|EMBL:EOB05566.1"
SQ SEQUENCE 3343 AA; 370910 MW; 299CDE3DD875DE1E CRC64;
TDLGPISLNW FEELSSEAPP YEPKLLELDA PIDQTSFKTP KAKPFTYSQL TSTPPIFKEQ
NTIMPPFSSP GIELDQKKIG TSRENFTSPS IIGRKRDQEN EMLASPLGTC HNFLAASPAI
LRNAFRTPQR SNIPGPYGSL FCTPKFLEVR TPKRISESLG AEVDPDMSWS SSLATPPTLG
ATVIIARETS SISGPKQQDE RAEIVLHSFS SDHDECPGKN DSSLLSIPET VKLNGEDVTK
EFESEMLDGF FGEMDSFENT LTVPAESSGT LLLLPHALDA IDKCETKRDE AQGEEDVPSE
QPVRRKTGIS QEVEMGNGAE KSHPIEMKDY LSQNADEDTG DSKDACLIGH EKELDLLRIT
GNMQDNGMEK SCENEKLVKD DVLSSSSQWS QLNLSGLDVT HLEMSTCSSP SIDLCTDKDL
KEKTALMAKD DAVGTSLLNT LGLKNAQQLL NASLSDMHEE MQKTGNNPTA EVTPVRSVHL
NPELVKGHAA EKVSKMSFIN CNSFLIKSTN VMEYSVVYNS SFSKCVKATS KSVVTDVLSH
PLVCSTSSPD NCSDLHFTSS ENTLTKSGFK SLNMLSRLKN KSKRFIYTIN NTLLYQEEKI
QKEVTSELPA DLMLPQLETD SHEFQGCHVA ADGDPDSLLS AERQLNIKED NLSTCVKKDL
EDNSSFDSRL KQQELRNLGK DTREYQPATS LKCLEVSNHQ KEDTTDSLNS ERISNIKRKV
LSASCLMARK RSRLFPEDCC LEKGEEDTSM SHNVNNGATV PQSLKRQPAQ AFPSNNDCLL
DVCHDITSVT NRDVNKTLSQ INFDINRVSS DSCSKISADE KHATDPLALV EHRQVLAPVG
MNCSGDDRIR LKQCGKKDVA AFSGDVADNQ ETRLVKSDES PEAAACNKVA VEIVEELLDC
IDDNSLIEVI SEEDKQVPPI YSHKEPNENL EHEGKSSGIV NVCRSNLSFG GFQTASNKQI
KFSEDSIAKG KMLFKDIENE CFEASYVERG RNFSNQVQKE NVFSSNLESK LGSALSGSQT
RRTQFTPHKV DLCKNFPRSL HSLQELNQTL TASQEAEIAE ISSILEETGS QFEFTQFRRQ
SNMVQSVEKQ DIVTVEMHGA ANVENNSEPW KDTDPCSTFK SENQVRNDKY CSTWKDTDEE
CKMVEYEKEN KVLFHKSSEE VTFSDRDESG VSDGESFPVP VQASVSNFVG FTSAGGKKIN
ISKAALTRSA ELFKDLDDNY LLKSSETNTG CGNSKGSRGM SSNWNSFRCL TKENKGVSNI
NSVGAISHAH SISHHSENVG TPEKENKENW TERLISDDER VDFSHANARH SAYGMRNSPT
SIQEQNQNHK IPKQVLNPGD CQAEDSLQED SLYVTCLGDA TATAEHCDLS ISDEMENLFP
AEKGEDSRQK DEHLPQKFQT SDGAISVSGG PLDNSLHGLS VNCGERDVDV SENSDKQKTT
GINIEGEDTT DESLFVNESR IKMGSYQHHQ VPFEQEVDVE PSEVKGSFLT GFQTASGKKI
TIADGFLAKA EQFFSEEDVD LGKEHNDNFE DHIKNRKRSV NCVKGCDLRI DNVAQCDAEK
LISEEPGIRF KQTRGSSPTK QAVILDSVKV DAFANIGEDS DRNLVAAYEK ADVQHGKSEL
ESLSEWESKA LSRTCLSEDG KLFAEMDVEC SAKKKDKSES THGFPVQSAI SLPSMKVSSN
PVDNSMPCDV KNTLFVEDSS KSDQSVLKAY SSVSQSHCPQ LNSDSKEFDV QHLNQPCSNT
SCFADAALTA HQKQSEVGLP EGGTNLACLQ ETSLNFNDGN PKGGLKQTVF STAKGKAVFV
SESALARVRQ MFQEDYGESV KHEIKTKSRT NQTEIPVNSS FVVPAECPNS TKFLDATKRE
GNSAASHFTD GNVNASEDSQ QDANPFEDEI SVPNSQVQGF GQNTALLGHV PVPNKQMKQS
DSSTSNLGFF STASGKPVQL SEESLKKARQ LFSEMESSHS SGLQEFQVEG DVEKSEKLAE
EVFPRKMQLE ERENASTKMI SGPAFGFSTA SGKQVTVSEN AYQKAKAILK ESDDFLSNEL
CIIDQLHAIK ESGHRTKSRT GNVISESKTD KSCDELDFKS IHPEEMKSSS STHHLKMPEY
VPHSKKNSQL ALVKNSFKQE ETGPVRKGLN LGMKTESEAV SCSATAKAEI NDELFQTPKS
HFKVGTVGNE KASVGDHLSD PGAKTNSAQS FCGKTSDKSF QNKTFGKRHF EEKNALGEPP
IKRQLLLEFD KTKMPPRSLK ASKSTPEGIF KDRRKFLYHV PLKPVTCQPF GASKERQEVR
NPTLTLPDQD FKGFKSKPAI FQHCALRQSS NDASRLSTPH KASAQESEEK RNLNKSGKTA
KTFVPPFKTK LTFSTSEQGS SKRCDSPISK NMTEEREINQ IRIEKDTAET RDHPSCILHA
ADTDLENGNL VMNKMMANLR CARDLQEMRI KKKFRQNISS QPGSLYVIKT SARNRISLKT
AVEEKSPSFY STEELYRYGV SKHCVQVNST NAESFQFLIK DFFSKEYLLA GNGIQLADGG
WLIPTDEGKA GKKEFYRALC DTPGVDPKLI TEAWVYNHYR WIVWKLAAME VAFPHEFATR
CLTPETVLLQ LKYRYDLEID KSKRSAIKKI TERDDAAGKT LVLCVSKIIS LNAVVSPSNN
NMESKKGAAI IEVTDGWYGI RALLDPPIKA FLHRRRLTVG QKIIVHGAEL VGSQNGCTPL
EAPDSLMLKI SANSTRCARW HAKLGFHRDP RPFPLPLSSL YSEGGAVGCI DVVIQRAYPI
QWMEKTSAGS YVFRNSRAEE REAARHAEDQ QKKLEALFAK IQAEFEKHEG KDFIISEYVI
TQKHFYTEYV FSWLQGYLSE DQLKALNAHR QLMNDKKQTR IQEEFKKAVE SAEKEKYGCS
KRDVSTVWKL CVVDYRKQEK HKGVILSIWR PPLDVCSLLK EGSRYRIYQL SASQSKGRAE
STNIQLTATK KTQYLQLSVS KKMLLQIFFP RKALKFTSLL DPSFQPPCAE VDLVGVVISV
SKTGFATMVY LSDESYNLVA IKVWADLRHF AIEDIVVRSS FISASNLQWQ SDFRSEIPML
VAGDLSVFSA SPKETYLQEK FNELRSLVEN VDSFCSDAES KLMNLLQRSQ SLTPTLPKRC
GSECFSPSCN SGLYAADKSL ISSSKMEIKY LSPLSTSTPN MKLVPQGSAK TPSFDEDHPK
NSKKRKAMDF LSCIPAPPPL TPICSTISPS LKKAFQPPRS LGLQRSKSGK ETNPNVGFVT
PSRKVREAVR VPVNDLVADE ELAMINTQAL INTLPEEKKT EGVNETSTIA TNLSDDLSSK
RSSRSTEEAK NSLKSSSEGA EALQEDIMSP QAPLSTHRML QQR
//