ID R0K979_ANAPL Unreviewed; 1198 AA.
AC R0K979;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
DE Flags: Fragment;
GN ORFNames=Anapl_04840 {ECO:0000313|EMBL:EOB06821.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB06821.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|RuleBase:RU000312};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC {ECO:0000256|RuleBase:RU000312}.
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DR EMBL; KB742580; EOB06821.1; -; Genomic_DNA.
DR AlphaFoldDB; R0K979; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd06263; MAM; 1.
DR CDD; cd05036; PTKc_ALK_LTK; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF276; ALK TYROSINE KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF12810; Gly_rich; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kinase {ECO:0000313|EMBL:EOB06821.1};
KW Membrane {ECO:0000256|RuleBase:RU000312};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW Receptor {ECO:0000256|RuleBase:RU000312, ECO:0000313|EMBL:EOB06821.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|RuleBase:RU000312};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 53..215
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 692..968
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 439..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1006..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 726
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOB06821.1"
FT NON_TER 1198
FT /evidence="ECO:0000313|EMBL:EOB06821.1"
SQ SEQUENCE 1198 AA; 129488 MW; AAE273368FCC317C CRC64;
SLGSASVSKM ALEGSFICWN GTSIRLGQAC DFIRDCLEGE DEGDMCKNLP PGFYCSFEEG
DCGWIHSSSA SRASPWRIGS PDYDRFPSIE GCGLIFDTSK APAAANTAIT STAFPAPLRN
SPCEASPSLR MSWLIHGVLL GNISLVLVEN KTGKEQSRTL WHSANSKGLG IWQWLILPLP
DILDRFWFQI IASWEEGSDA IIAFDNVSLS LDCYLTINGE KIPRSTTPDS SNLLTSRGGK
KKTAILFLGV QSMLVLISDH WLFTTCGASG PYGPTQSQCN NAYRNSNLSV VVGAEGILQG
IQIWRVPATN TYSISGYGAA GGKGGKNTMV RSHGVSVLGI FDLQKDDTLY ILVGQQGEDA
CPSTNDVIQK VCIGENNVIE EEIRVNRSVN EWAGGGGGGG GATYIFKMEN GEPVPLIIAA
GGGGRAYRAK TDTFHPERLE NDSSVPGLNG NSGAAGGGGG WNDNTSFLWS GKSLLEGATG
GRSCPQAMKK WGWETRGGFG GGGGGCSSGG GGGGYIGGNA AEDNDPEMDG EDGVSFINPI
GTLYTPALKV TEGHGEVDIR LHLNCSHCEM DECRVDPETQ KVICFCEPGT ELAEDGVSCV
AEPVVHLPLS LVLSVVTSAL VAALILAFSG IMIVYRRKHQ ELQAMQMELQ SPEYKLSKLR
TSTIMTDYNP NYCFAGKTTS ISDLKEVPRK NISLIRGLGH GAFGEVYEGQ VAGIPSDPTP
LQVAVKTLPE VCSEQDELDF LMEALIISKF NHQNIVRCIG VSLQALPRFI LLELMAGGDL
KSFLRETRPR PNQPSSLSML DLLHVARDIA CGCQYLEENH FIHRDIAARN CLLTCRGPGR
VAKIGDFGMA RDIYRASYYR KGGCAMLPVK WMPPEAFMEG IFTSKTDTWS FGVLLWEIFS
LGYMPYPSKS NQEVLEFVTN GGRMDPPKNC PGPVYRIMTQ CWQHQPEDRP NFAIILERIE
YCTQDPDVIN TALPVEYGPS VEEEEKVAIH PEDPEGIPPL LVSAHQDRKD DKQTLPSPPP
LPSAITAGKA LGKAGALEPP VPGKVQSASA GGHINMAYTQ SNPPSELHKG RGSRNKPTNL
WNPTYGSWFA EKQASRNNPL LEKEMPEREN LGHEGNCTVG PNIVTGRLPG SSLLLEPSSL
TASVKEVPLF RLRHFPCGNV NYGYQQQGLP LEASTPPCAS SYEDPALRNK SHITQHGP
//
