ID R0KU12_NOSB1 Unreviewed; 351 AA.
AC R0KU12;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Mechanosensitive ion channel MscS domain-containing protein {ECO:0000259|Pfam:PF00924};
GN ORFNames=NBO_31g0010 {ECO:0000313|EMBL:EOB14291.1};
OS Nosema bombycis (strain CQ1 / CVCC 102059) (Microsporidian parasite)
OS (Pebrine of silkworm).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae; Nosema.
OX NCBI_TaxID=578461 {ECO:0000313|EMBL:EOB14291.1, ECO:0000313|Proteomes:UP000016927};
RN [1] {ECO:0000313|EMBL:EOB14291.1, ECO:0000313|Proteomes:UP000016927}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQ1 / CVCC 102059 {ECO:0000313|Proteomes:UP000016927};
RX PubMed=23496955; DOI=10.1186/1471-2164-14-186;
RA Pan G., Xu J., Li T., Xia Q., Liu S.L., Zhang G., Li S., Li C., Liu H.,
RA Yang L., Liu T., Zhang X., Wu Z., Fan W., Dang X., Xiang H., Tao M., Li Y.,
RA Hu J., Li Z., Lin L., Luo J., Geng L., Wang L., Long M., Wan Y., He N.,
RA Zhang Z., Lu C., Keeling P.J., Wang J., Xiang Z., Zhou Z.;
RT "Comparative genomics of parasitic silkworm microsporidia reveal an
RT association between genome expansion and host adaptation.";
RL BMC Genomics 14:186-186(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB908939; EOB14291.1; -; Genomic_DNA.
DR AlphaFoldDB; R0KU12; -.
DR STRING; 578461.R0KU12; -.
DR EnsemblFungi; EOB14291; EOB14291; NBO_31g0010.
DR VEuPathDB; MicrosporidiaDB:NBO_31g0010; -.
DR HOGENOM; CLU_060783_0_0_1; -.
DR OMA; YRITEYI; -.
DR Proteomes; UP000016927; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR016688; MscS-like_plants/fungi.
DR InterPro; IPR006685; MscS_channel_2nd.
DR PANTHER; PTHR31618:SF7; MECHANOSENSITIVE ION CHANNEL PROTEIN; 1.
DR PANTHER; PTHR31618; MECHANOSENSITIVE ION CHANNEL PROTEIN 5; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016927};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 193..259
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT COILED 273..300
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 351 AA; 41318 MW; 7DAFE1631E9E3C18 CRC64;
MENFVHITLG VSLVMFLYLI KTIVLEGIDY MMYWCSYFQK LIQTNKDVQT LNLVNSVTQK
TITLRSPEWI SYVFKVLSPE GTPLNRDTLE YFFSATETDE ILALFDRHNT GSIDEKTFID
TWLNVAYEKK KIKNVVEYKN VLLKKLDYLF SFIFIPIMLF TFMTILGKTE YFTTYGSIVV
GFILPLSFIF AGVIGDLFKS IVFVFFVRPF EVGDKIEMMD KIYIVDEIGL LYSTFLNNSL
NVTMSNIEIM NKNIVNYRRS EFYEKKYTLK FDIDVYKRVV DDFKKELKNL IDEHSKLLKK
KFKLENIVVK EEGKLEVDLI IYADIHSHNL MEGIDEFSIR LDKLVNEIKQ K
//
