ID R0KWW3_ANAPL Unreviewed; 902 AA.
AC R0KWW3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
DE Flags: Fragment;
GN ORFNames=Anapl_07978 {ECO:0000313|EMBL:EOA97788.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOA97788.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; KB743609; EOA97788.1; -; Genomic_DNA.
DR AlphaFoldDB; R0KWW3; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08799; Death_UNC5C; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042154; Death_UNC5C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF7; NETRIN RECEPTOR UNC5C; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 351..376
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 127..208
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 504..638
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 837..902
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOA97788.1"
FT NON_TER 902
FT /evidence="ECO:0000313|EMBL:EOA97788.1"
SQ SEQUENCE 902 AA; 100324 MW; EBAC7E62BE09A7A2 CRC64;
LPETFPSDPP EPLPHFLIEP EEAYIVKNKP VNLYCKASPA TQIYFKCNSE WVHQKDHVVD
ERVDETSGLI VREVSIEISR QQVEELFGPE DYWCQCVAWS SAGTTKSRKA YVRIAYLRKT
FEQEPLGKEV SLEQEVLLQC RPPEGIPVAE VEWLKNEEVI DPVEDRNFYI TIDHNLIIKQ
ARLSDTANYT CVAKNIVAKR KSTTATVIVY VNGGWSTWTE WSVCNSRCGR GFQKRTRTCT
NPAPLNGGAF CEGQSVQKIA CTTLCPVDGK WTSWSKWSTC GTECTHWRRR ECTAPAPKNG
GKDCEGLVLQ SKNCTDGLCM QEYFLKSPCE DCIALRFLAS LPLAAPDSDD VALYVGIVIA
VIVCLAISVV VALFVYRKNH RDFESDIIDS SALNGGFQPV NIKAARQDLL AVPPDLTSAA
AMYRGPVYAL HDVSDKIPMT NSPILDPLPN LKIKVYNTSG AVTPQDDLSD FSSKLSPQIT
QSLLENETLN MKNQSLARQT DPSCTAFGTF NSLGGHLIIP NSGVSLLIPA GAVPQGRVYE
MYVTVHRKES MRPPIEDSQT LLTPVVSCGP PGALLTRPVV LTMHHCAEPN TDDWQIHLKH
QAAQGPWEDV VVVGEENFTT PCYIQLDPEA CHILTETLST YALVGQSITK AAAKRLKLAI
FGPLSCSSLE YNIRVYCLDD TQDALKEVLQ LERQMGGQLL EEPKTLHFKG STHNLRLSIH
DIAHSLWKSK LLAKYQEISF YHIWSGGQRN LHCTFTLERF SLNTLELVCK LCVRQVEGEG
QIFQLNCSVS EEPTGIDYPV MDSAGTITTI VGPNAFSIPL PIRQKLCSSL DAPQTRGHDW
RMLAHKLKLD RYLNYFATKS SPTGVILDLW EAQNFPDGNL SMLAAVLEEM GRHETVVSLA
AE
//
