ID R0KYM2_ANAPL Unreviewed; 1120 AA.
AC R0KYM2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=Cytospin-A {ECO:0000256|ARBA:ARBA00015657, ECO:0000256|RuleBase:RU367063};
DE Flags: Fragment;
GN ORFNames=Anapl_06129 {ECO:0000313|EMBL:EOA98358.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOA98358.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- FUNCTION: Involved in cytokinesis and spindle organization. May play a
CC role in actin cytoskeleton organization and microtubule stabilization
CC and hence required for proper cell adhesion and migration.
CC {ECO:0000256|ARBA:ARBA00025131, ECO:0000256|RuleBase:RU367063}.
CC -!- SUBUNIT: May interact with both microtubules and actin cytoskeleton.
CC {ECO:0000256|ARBA:ARBA00011235, ECO:0000256|RuleBase:RU367063}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186, ECO:0000256|RuleBase:RU367063}.
CC Cytoplasm, cytoskeleton {ECO:0000256|RuleBase:RU367063}. Cell junction,
CC gap junction {ECO:0000256|RuleBase:RU367063}.
CC -!- SIMILARITY: Belongs to the cytospin-A family.
CC {ECO:0000256|ARBA:ARBA00009452, ECO:0000256|RuleBase:RU367063}.
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DR EMBL; KB743518; EOA98358.1; -; Genomic_DNA.
DR RefSeq; XP_005023615.1; XM_005023558.2.
DR AlphaFoldDB; R0KYM2; -.
DR GeneID; 101801274; -.
DR KEGG; apla:101801274; -.
DR CTD; 23384; -.
DR HOGENOM; CLU_009328_1_0_1; -.
DR OMA; HEAATYE; -.
DR OrthoDB; 5393863at2759; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR CDD; cd21199; CH_CYTS; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR PANTHER; PTHR23167; CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED; 1.
DR PANTHER; PTHR23167:SF18; CYTOSPIN-A; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|RuleBase:RU367063};
KW Cell division {ECO:0000256|RuleBase:RU367063};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949,
KW ECO:0000256|RuleBase:RU367063}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU367063};
KW Cytoskeleton {ECO:0000256|RuleBase:RU367063};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW ECO:0000256|RuleBase:RU367063};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049}.
FT DOMAIN 1014..1119
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 246..273
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 414..444
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 491..808
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1120
FT /evidence="ECO:0000313|EMBL:EOA98358.1"
SQ SEQUENCE 1120 AA; 125130 MW; 44C79C29639B953B CRC64;
MKKASRSVGS VPKVPGVNKT QTTEKNKPEN GSSLSAVTKL SKTGTSASLL KTKSNDDLLA
GMAGGGGVTM TNGVKAKKST CVSTVSSAAG TTMNSLENKP KTVAGTSSTT KRSTSSGNKE
SSSSRERIRD RSRLSQSKKL PLTGQGTNDT VLAKRSRSRT NPESDIRMSK SKSDNQISDK
AALEAKVNDL LTLAKTKDVE ILHLRNELRD MRAQLGLNED QVEGDEKSEE KEAIVVHQPT
DVESTLLQLQ EQNTAIREEL NQLKNENRML KDRLNALGFS LEQRLDNSEK LFGYQSLSPE
ITAGNHSDGG GTLTSSVEGS APGSMEDLLS QDENTLMDNQ HSNSMDNLDS ECSEVYQPLT
SSDDALDAPS SSESEGVPSI ERSRKGSSGN ASEVSVACLT ERIHQMEENQ HSTAEELQAT
LQELADLQQI TQELNSENER LGEEKVILME SLCQQSDKLE HFSRQIEYFR SLLDEHHISY
VIDEDMKSGR YMELEQRYMD LAENARFERE QLLGVQQHLS NTLKMAEQDN KEAQEMIGAL
KERNHHMERI IESEQKSKTA IASTLEEYKA TVASDQIEMN RLKAQLEHEK QKVAELYSIH
NSGDKSDIQD LLESVRLDKE KAETLASSLQ EELAHTRNDA NRLQDAIAKV EDEYRVFQEE
AKKQIEDLNV TLEKLRTELD EKETERSDMK ETIFELEDEV EQHRAVKLHD NLIISDLENT
VKKLQDQKHD MEREIKNLHR RLREESAEWR QFQADLQTAV VIANDIKSEA QEEIGDLKRR
LHEAQEKNEK LTKELEEIKS RKQEEERGRV YNYMNAVERD LAALRQGMGL SRRSSTSSEP
TPTVKTLIKS FDSASQVPSP AAAAIPRTPL SPSPMKTPPA AAVSPMQRHS ISGPISTSKP
LATLTDKRPS YAEIPVQEHL LRTSSTSRPA SLPRVPAMES AKSISVSRRS SEEIKRDISA
PDGASPASLM AMGTTSPQLS LSSSPTASVT PTTRSRIREE RKDPLSALAR EYGGSKRNAL
LKWCQKKTEG YQNIDITNFS SSWNDGLAFC AVLHTYLPAH IPYQELNSQD KRRNFTLAFQ
AAESVGIKST LDINEMVRTE RPDWQNVMLY VTAIYKYFET
//
