ID R0KZE2_ANAPL Unreviewed; 399 AA.
AC R0KZE2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=P2X purinoceptor {ECO:0000256|RuleBase:RU000681};
DE Flags: Fragment;
GN ORFNames=Anapl_02636 {ECO:0000313|EMBL:EOA98693.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOA98693.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|EMBL:EOA98693.1}
RP NUCLEOTIDE SEQUENCE.
RA Li N.;
RT "The genome sequence and transcriptome of duck provide insight into the
RT interaction host.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for ATP that acts as a ligand-gated ion channel.
CC {ECO:0000256|RuleBase:RU000681}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000681}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000681}.
CC -!- SIMILARITY: Belongs to the P2X receptor family.
CC {ECO:0000256|ARBA:ARBA00009848, ECO:0000256|RuleBase:RU000681}.
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DR EMBL; KB743446; EOA98693.1; -; Genomic_DNA.
DR AlphaFoldDB; R0KZE2; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004931; F:extracellularly ATP-gated monoatomic cation channel activity; IEA:InterPro.
DR GO; GO:0001614; F:purinergic nucleotide receptor activity; IEA:InterPro.
DR GO; GO:0033198; P:response to ATP; IEA:InterPro.
DR Gene3D; 1.10.287.940; atp-gated p2x4 ion channel; 1.
DR Gene3D; 2.60.490.10; atp-gated p2x4 ion channel domain; 1.
DR InterPro; IPR003048; P2X5_purnocptor.
DR InterPro; IPR027309; P2X_extracellular_dom_sf.
DR InterPro; IPR001429; P2X_purnocptor.
DR NCBIfam; TIGR00863; P2X; 1.
DR PANTHER; PTHR10125; P2X PURINOCEPTOR; 1.
DR PANTHER; PTHR10125:SF12; P2X PURINOCEPTOR 5; 1.
DR Pfam; PF00864; P2X_receptor; 1.
DR PIRSF; PIRSF005713; P2X_purinoceptor; 1.
DR PRINTS; PR01312; P2X5RECEPTOR.
DR PRINTS; PR01307; P2XRECEPTOR.
DR PROSITE; PS01212; P2X_RECEPTOR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR005713-1};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR005713-2};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU000681};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000681};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000681};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR005713-1};
KW Receptor {ECO:0000256|RuleBase:RU000681};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000681};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000681};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000681}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000681"
FT TRANSMEM 341..363
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000681"
FT REGION 376..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 69..71
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-1"
FT BINDING 189
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-1"
FT BINDING 295..297
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-1"
FT BINDING 315
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-1"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-3"
FT DISULFID 118..169
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-2"
FT DISULFID 129..152
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-2"
FT DISULFID 135..163
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-2"
FT DISULFID 220..229
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-2"
FT DISULFID 263..272
FT /evidence="ECO:0000256|PIRSR:PIRSR005713-2"
FT NON_TER 399
FT /evidence="ECO:0000313|EMBL:EOA98693.1"
SQ SEQUENCE 399 AA; 44682 MW; 864548D3378EE40C CRC64;
MGQVAWKGLF LSLFDYKTEK YVIAKNKKVG ILYRVVQLSI LAYLVGWVFV VKKGYQDTDT
SLQSSVITKL KGVAFTNTSE LGERLWDVAD YVIPPQGENV FFVMTNLIVT PNQKQATCPE
SASIPDALCY KDGDCPAGQA VVAGNGVKTG RCLKERDSIR GTCEILAWCP VEKRSKPKKP
LLASAENFTV YIKNSIRFPK FKFSKMNVLV TDNESYLKSC RYSTEHPYCP IFLLGNIVRW
AGSDFHEMAL EGGVIGIQIE WNCDLDKAPS ECNPHYSFSR LDNKFAEKSI SSGYNFRFAK
YYRDANGVDY RTLFKAYGIR FDVMVNGKAG KFNIIPTVIN IGSGLALMGA GAFFCDLVLL
YLIKKSNFYR GKKYEEVKSS SRKSLSSPTL NGNQSPDQL
//
