ID R0KZT0_ANAPL Unreviewed; 884 AA.
AC R0KZT0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Phosphoinositide 3-kinase regulatory subunit 5 {ECO:0000256|ARBA:ARBA00040195};
DE Flags: Fragment;
GN ORFNames=Anapl_12591 {ECO:0000313|EMBL:EOA93512.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOA93512.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KB746093; EOA93512.1; -; Genomic_DNA.
DR AlphaFoldDB; R0KZT0; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005944; C:phosphatidylinositol 3-kinase complex, class IB; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR019522; PIK3R5/6.
DR PANTHER; PTHR15593; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR15593:SF2; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5; 1.
DR Pfam; PF10486; PI3K_1B_p101; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000313|EMBL:EOA93512.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Transferase {ECO:0000313|EMBL:EOA93512.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 75..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 312..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..335
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 884
FT /evidence="ECO:0000313|EMBL:EOA93512.1"
SQ SEQUENCE 884 AA; 98274 MW; 34AC53E7F3D0E279 CRC64;
MQHTTCTEDR IYHALERCLH GLSRDAVSSR WAAGLCLNCW SLQELVSRDA GNYLILVEKI
LCKAKEVQEK CDYDLVMPLA LLFYYAVLCA PYIPPGSELL LKAASIYHSF LTWPVPYCDI
FRELLTFISD ELKAPGISFQ RLVRTEQGLS VKNSQSSTVT VLLLNRSEVQ SEFLSIAEKL
SGTEPPRHAT LVLLLEHLYQ ATFGTRCDLD SLRRLLKAKP LEELSEVYAS AAEAQEIAAA
SGDPALARER LQGFLVLSLN PCGIKERAGH AAGRVLVWGV QFPTGPVPDL ISLLCLSDVL
NDVLSKECNF VEPVASENEE DEEEEEEEED VETDGCSPER DSLLSPISTI SKDSMYSALA
EEGPKHSRMS LFTASKDSIS ELTVVSRKSL RSFVSSLKDC MDSGYAEDSD ESSLDAVGRP
ELKVEKPHHK YRHTLTNKIY KLFKSKSQLV LRRDLKGCPD TGSLPLRRAE SLCHPQAKHR
VPARSRRAHS LPQHVLSQRL QALHAPRLLS LPRRPFLSYD EDAKVSTLRV VVFGSDRISG
KVARAYSNLR LKESTCPTLT RYFKLQFFYI PVKRSCLAPV APLTHPPPSP GDLQLRASAQ
AESTLAGVES STNDISHYIG MLDPWYERNV LGLMNLPMDV LCQSAKPEAE PQGDSREQLP
ILADMILYYC RFATRPVLLQ LYQTELTFIG GEKMTEVFIH SLELGHSAAT RAIKASGPGS
KRLGIDGDRE AIPLTLQIAY SKTAVSGRSH WNDVEKVCTS VNLSKACKKY EELASKTECL
NLTMTEVVKR QNSKSKKSFN QLSVSQIKVD KVQIIGVQSS FAVCLDQDEQ KILQSVTRCE
ISVCYKPRDS DSLALSRSSL TPQDPSEFHS LLCLPISTFS GALP
//
