ID R0L3H5_ANAPL Unreviewed; 635 AA.
AC R0L3H5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
DE Flags: Fragment;
GN ORFNames=Anapl_18557 {ECO:0000313|EMBL:EOA94807.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOA94807.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; KB744573; EOA94807.1; -; Genomic_DNA.
DR AlphaFoldDB; R0L3H5; -.
DR HOGENOM; CLU_002173_9_4_1; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR11254:SF363; E3 UBIQUITIN-PROTEIN LIGASE HACE1; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 300..635
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 121..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 602
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOA94807.1"
FT NON_TER 635
FT /evidence="ECO:0000313|EMBL:EOA94807.1"
SQ SEQUENCE 635 AA; 72043 MW; 1F9FBC9C0A9674B0 CRC64;
SLSSNYEAQM KSLLRIVRIF CHVFRIGPSS PSNGNDMGYN GNKTPRSQVF KVRKVYDVVR
KIDVKEMNFT KHAFINQTSH EQEPLELLWH SLDEWLVLIA TELMKNKRDS ANITSILLKQ
KGPDHQDATP TPSFATAGTE STKELSTDTG DSKTYEVAGK QEACADCQDV ISMTANRLSA
VIQAFYMCCS CQMPQGMTSP RFIEFVCKHD DVLKCFVNRN PKIIFDHFHF LLECPELMSR
FMHIIKAQPF KDRCEWFYEH LHSGQPDSDM VHRPVNENDI LLVHRDSIFR SSCEVVSKAN
CAKLKQGIAV RFHGEEGMGQ GVVREWFDIL SSEIVNPDYA LFTQSADGTT FQPNSNSSVN
PDHLNYFRFA GQILGLALNH RQLVNIYFTR SFYKHILGIP VNYQDVASID PEYAKNLQWI
LDNDISDLGL ELTFSVETDV FGAMEEVPLK PGGASILVTQ ENKAEYVQLV TELRMTRAIQ
PQINAFLQGF HMFIPPSLIQ LFDEYELELL LSGMPEIDVN DWLKNTEYTS GYERGDQVIQ
WFWDVVEELT QEERVLLLQF VTGSSRVPHG GFAHIMGGSG LQNFTIAAVP YTANLLPTSS
TCINMLKLPE YPSKEILKDR LLVALHCGSY GYTMA
//