ID R0L8U2_ANAPL Unreviewed; 141 AA.
AC R0L8U2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Interleukin-4 {ECO:0000256|ARBA:ARBA00019467};
DE AltName: Full=B-cell stimulatory factor 1 {ECO:0000256|ARBA:ARBA00031287};
DE AltName: Full=Lymphocyte stimulatory factor 1 {ECO:0000256|ARBA:ARBA00030247};
DE Flags: Fragment;
GN Name=IL4 {ECO:0000313|Ensembl:ENSAPLP00020008339.1};
GN ORFNames=Anapl_13976 {ECO:0000313|EMBL:EOA97844.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOA97844.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|EMBL:EOA97844.1}
RP NUCLEOTIDE SEQUENCE.
RA Li N.;
RT "The genome sequence and transcriptome of duck provide insight into the
RT interaction host.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
RN [3] {ECO:0000313|Ensembl:ENSAPLP00020008339.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; KB743600; EOA97844.1; -; Genomic_DNA.
DR RefSeq; XP_012959476.1; XM_013104022.1.
DR Ensembl; ENSAPLT00020008975.1; ENSAPLP00020008339.1; ENSAPLG00020006119.1.
DR GeneID; 106018562; -.
DR KEGG; apla:106018562; -.
DR HOGENOM; CLU_1864510_0_0_1; -.
DR OMA; AQVPCND; -.
DR OrthoDB; 4419294at2759; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR Proteomes; UP000694400; Chromosome 14.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR PANTHER; PTHR47401; INTERLEUKIN-4; 1.
DR PANTHER; PTHR47401:SF1; INTERLEUKIN-4; 1.
DR Pfam; PF00727; IL4; 1.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 4: Predicted;
KW B-cell activation {ECO:0000256|ARBA:ARBA00022936};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..141
FT /note="Interleukin-4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015101095"
FT NON_TER 141
FT /evidence="ECO:0000313|EMBL:EOA97844.1"
SQ SEQUENCE 141 AA; 15585 MW; A2AE01EEC8E2ABC2 CRC64;
MFSPLKAAFA LLYLAELISS RPLTTTSSTA SRLKLSEITH RIQQLNTGVQ VPCNDTRVAQ
VAFTDRKLSE HDLLCQAATA LAKVTRCKND YEPLIINLKS LHGKAGCSLS TDNEIYLRNF
LPELGNFTQA LYRRLATTAA N
//
