ID R0L9V8_ANAPL Unreviewed; 974 AA.
AC R0L9V8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 03-MAY-2023, entry version 35.
DE SubName: Full=Retinoblastoma-like protein 1 {ECO:0000313|EMBL:EOB02404.1};
DE Flags: Fragment;
GN ORFNames=Anapl_04451 {ECO:0000313|EMBL:EOB02404.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB02404.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; KB742967; EOB02404.1; -; Genomic_DNA.
DR AlphaFoldDB; R0L9V8; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20605; CYCLIN_RBL1; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF20; RETINOBLASTOMA-LIKE PROTEIN 1; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR Pfam; PF08934; Rb_C; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..117
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 290..483
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 696..788
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 858..974
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOB02404.1"
FT NON_TER 974
FT /evidence="ECO:0000313|EMBL:EOB02404.1"
SQ SEQUENCE 974 AA; 110527 MW; 60CF4E60AF012AA7 CRC64;
LSLIQFFSKM KKWMDMSNLP QEFRERVERL ERNFEVSTVI FKKFEPIFLD VFQNPFEETS
KPQRSRKQRR VPCSVKDLFN FCWTLFVYTK GNFRMIGDDL VNSYHLLLCC LDLVFANALL
CPNRRDLLNP SFKGLPEDFH ATEIKVSEDP PCIIATLCEL HDGLLVEAKG IKEHYFKPYI
SKLFDRKILK GECLLDLCNF TENNKALNKE YEEYVLTVGD FDERVFLGAD AEEEIGTPRK
FPADMPVGKT AARAHVECHL QQHFEKKRSF APSTPLTGRR YLREKEAVIT PVASATQSVS
RLQNIVAGLK NAPSEQLITI FESCARSPME SITNRVKEIG ETFCRSYTQS TDEQPGSHID
FAVNRLKLAE ILYYKILETI MVQETRRLHG KDMTALLEQD VFHRSLMACC LEIVLFAYSS
PRTFPWIIEV LDLRPFYFYK VIEVLIRSEE GLSRDMVKHL NSIEEQILES LAWTRDSALW
SALQASENRV PTCEEVIFPS NFEASNGGSG LGHLPMMPVS PIVHPRVKEV RTDLGGTLRR
DLQPLSPISV HERYSSPTAG SAKRRLFGDD SPKEMQMEKI LTEGTKLTIA PASSIATENI
SVSPGQTVLT MTTATVPGKA GQKVTIPLHG IAHEMGGITL IPISMNLGQP PKMEAQAPYH
PQVSQAQEGH LSSGSKPKKT GSLALFYRKV YHLASVRLRD LCLKLDVSND LRRKIWTCFE
FTLVHCADLM KDRHLDQLLL CAFYIMAKVT KEERTFQDIM KSYRNQPQAN SHVYRSVLLR
NYSDDVLLDK NKNQDVEMTE GSFLLLLDSS VKTGSSSGRS AAEKSSESGT EERGDLITFY
NAVYVGRVQS FALKYDITNQ DHVMEAPPLS PFPNIKQQPV SPRRISQQHS VYVSPHKNGA
CLTPRTALLY KFNGSPSKSL KDINNMIKQG EHRSKKRAIT IDSDTESPTK RLCQENDDVL
LKRLQDVVSE RANH
//
