ID R0LJ55_ANAPL Unreviewed; 1127 AA.
AC R0LJ55;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Sodium channel protein type 5 subunit alpha {ECO:0000313|EMBL:EOB01725.1};
DE Flags: Fragment;
GN ORFNames=Anapl_16944 {ECO:0000313|EMBL:EOB01725.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB01725.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
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DR EMBL; KB743054; EOB01725.1; -; Genomic_DNA.
DR AlphaFoldDB; R0LJ55; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR01666; NACHANNEL5.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000313|EMBL:EOB01725.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 129..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 757..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..846
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 955..980
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..424
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 564..706
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 756..986
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 994..1126
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT REGION 482..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 415..446
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 498..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOB01725.1"
FT NON_TER 1127
FT /evidence="ECO:0000313|EMBL:EOB01725.1"
SQ SEQUENCE 1127 AA; 127623 MW; A7969314E4F1A9C4 CRC64;
QDEKMADFLL PPGTNSFHRF TPESLAAIEK RIAEKFARNA KQEYREQLGE EEKPQPQFDL
QACKKLPDIY GTVPPELIGE PLEDIDPFYN DRKTFVVLNK GKTIFRFSAT PALYILSPFH
PIRRAAIKIL LFTLFSMFIM CTILTNCVFM AQSETPPWNK YVEYTFTGIY TFESLIKILA
RGFCMTEFTF LRDPWNWLDF SVIVMAYITE FVDLGNVSAL RTFRVLRALK TISVISGLKT
IVGALIQSVK KLADVMILTV FCLSVFALIG LQLFMGNLRH KCVRDYTMFN STNGTFYLDG
RTWNSSEEFL NDPVNYFIKN GTEDVLLCGN STDAGTCPEG YICLKAGENP DHGYTSFDTF
GWAFLSLFRL MTQDYWERLY QQTLRSAGKI YMLFFMLVIF LGSFYLVNLI LAVVAMAYEE
QNQATIAETE EKERKFREAM EMLKKEQEVS KLHDAISFGN IATQAIAAKG IDSMSLSSLE
MSPLASKNAK ERRNRRKKKK SSGEEYGEDQ RNPKCEYDDG QRRMVSHALK HHLFLTALHW
IGQALNMHLK LKLPAGKKNQ YLITSHGSIF SFRLRGRDTG SETDFADDEI STAGENESHR
GSLLIPRSGR RPSVQSQVSH SSHPTTPNYT QTGKRNSSVD CNGVVSLIGG GTGALNPDPT
SPAGLLLPPV IMEKPGTGDL LLMPHRPSVD HSDEPFQRQR AVSAVSIITS ALEELEESHQ
KCPPCWNHFA VKFLIWDCCP LWLLIKKFVK FVVMDPFTDL TITLCIVLNT LFMALEHYKM
TKEFDHMLYI GNLVFTGIFT AEMIFKVIAL DPYYYFQQGW NIFDSIIVIL SLMELGLSSM
GNLSVLRSFR LLRVFKLAKS WPTLNTLIKI IGNSVGALGN LTLVLAIIVF IFAVVGMQLF
GKSYMDNVKK ISTTGNLPRW HMNDFFHSFL IIFRILCGEW IETMWDCMEV AGQPLCLLVF
LLVMVIGNLV VLNLFLALLL SSFSADNLSA PDEDGEMNNL QLAFARINRG LQYVKRTTWD
FCCNVLRHPK TTAEKKAMMK LAAQNTGALN NCVNSHTTAE FGKDMENHKE NHTEDGMNKN
GDKHLGITDN DDFMTNPDLS ICVPIAVGES DIEEEDEEQS TFTEMEQ
//
