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Database: UniProt
Entry: R0LKW7_ANAPL
LinkDB: R0LKW7_ANAPL
Original site: R0LKW7_ANAPL 
ID   R0LKW7_ANAPL            Unreviewed;      2767 AA.
AC   R0LKW7;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
DE   Flags: Fragment;
GN   ORFNames=Anapl_10950 {ECO:0000313|EMBL:EOB01088.1};
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB01088.1, ECO:0000313|Proteomes:UP000296049};
RN   [1] {ECO:0000313|Proteomes:UP000296049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23749191; DOI=10.1038/ng.2657;
RA   Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA   Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA   Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA   Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA   Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA   Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA   Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA   Rao M., Pitel F., Wang J., Li N.;
RT   "The duck genome and transcriptome provide insight into an avian influenza
RT   virus reservoir species.";
RL   Nat. Genet. 45:776-783(2013).
CC   -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC       that mediates the release of intracellular calcium.
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|RuleBase:RU368044}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC       extremity. Its large N-terminal cytoplasmic region has the ligand-
CC       binding site in the N-terminus and modulatory sites in the middle
CC       portion immediately upstream of the channel region.
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC       {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR   EMBL; KB743136; EOB01088.1; -; Genomic_DNA.
DR   Proteomes; UP000296049; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.80.10.50; -; 2.
DR   Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR45816:SF2; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR   PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR   SUPFAM; SSF82109; MIR domain; 2.
DR   PROSITE; PS50919; MIR; 3.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU368044};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW   ECO:0000256|RuleBase:RU368044};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW   ECO:0000256|RuleBase:RU368044};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU368044};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU368044};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW   ECO:0000256|RuleBase:RU368044};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW   Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU368044};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU368044};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT   TRANSMEM        2289..2311
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2323..2341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2347..2373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2409..2434
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2455..2477
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2588..2611
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   DOMAIN          112..166
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   DOMAIN          231..287
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   DOMAIN          379..435
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   REGION          324..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1142..1174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1702..1736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1756..1792
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1884..1906
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1933..1956
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2738..2767
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1150..1168
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1709..1724
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1885..1906
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         2767
FT                   /evidence="ECO:0000313|EMBL:EOB01088.1"
SQ   SEQUENCE   2767 AA;  315223 MW;  C8B1B8B73A676793 CRC64;
     MTDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
     RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEVNP DYEEDDQECQ SSLDPEQDAS RRGLRDAQEK MAYSLVSVPE
     GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT
     SPVKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL
     VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDS GDGPMLRLEE
     LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH
     NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPA
     NADILIETKL VLSRFEFEEV SSGENALEVG EDEEEVWLFW RDSNKEIRSK SIRELAQDAK
     EGQKEDRDVL SYYRYQLNLF ARMCLDRQYL AINEISGQLD VDLILRCMSD ENLPYDLRAS
     FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD SSGTSKDEIK ERFAQTMEFV
     EEYLRDVVCQ RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FCDLLRLTKI LLAILDCVHI
     TTIFPITKMA KGEESKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPLAAA PEGNVKQSEP
     EKEDILVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKHE FDESNAQMTE SPTGSSSQEM
     PANVPGALDF EHIEEQAEGI FGGRKVSLHE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL
     VSGALQLLFR HFSQRQEVLQ AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK
     GQGPDEAMDG VQGENEHKKK EEGHSKSQKP ESTSSYNYRV VKEILLRLSK LCVQEGISVR
     KSRKQQQRLL RNMGAHAVVL ELLQIPYEKA EDTRMQEIMK LAHEFLQNFC AGNQQNQALL
     HKHINLFLNP GILEAVTMQH IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI
     VKAEGKFIKK CQDMVMAELV NAGEDVLVFY NDRASFQTLV QMMRSERDRM DENSPLMYHI
     HLVELLAVCT EGKNVYTEIK CNSLLPLDDI VRVVTHEDCI PEVKIAYINF LNHCYVDTEV
     EMKEIYTSNH MWKLFENFLV DICRACNNTS DRKHADSILE KYVTEIVMSI VTTFFSSPFS
     DQSTTLQTRQ PVFVQLLQGV FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD
     SQVNNLFLKS HNIVQKTAMN WRMTARNAAR RDSVLAASRD YRNIIERLQD IVSALEDRLR
     PLVQAELSVL VDVLHRPELL FPENTDARRK CESGGFICKL IKHTKQLLEE NEEKLCIKVL
     QTLREMMTKD RGYGEKQITI ELDNAELPQP PETESSVEQE LDQTLPQRQL EDHRRGEALR
     QVLVNRYYGN VRPAGRRESL TSFGNGPLSA GGASKAGAGG GSSGSSSMSR GEMSLADVQC
     HLDKEGASNL VIDLIMNATS DRVFHESILL AIALLEGGNT TIQHSFFCRL TEDKKSEKFF
     KVFYDRMKVA QQEIKATVTV NTSDLGNKKK DEDSDRDVPT RKKAREPMTQ ITEEVRDQLL
     EASAATRKAY STYRREADSD DHYSAGEGAQ PAADKNKDDL EMSAVISIMQ PILRFLQLLC
     ENHNRDLQNF LRCQNNKTNY NLVCETLQFL DCICGSTTGG LGLLGLYINE KNVALINQTL
     ESLTEYCQGP CHENQNCIAT HESNGIDIIT ALILNDINPL GKKRMDLVLE LKAMTGGVLP
     SPQNNASKLL LAIMESRHDS ENAERILYNM RPKELVEVIK KAYLQGEVEF EDGENGEDLA
     ASPRNVGHNI YILAHQLARH NKELQNMLKP GGQIEGDEAL EFYAKHTAQI EIVRSDRTME
     QIVFPVPSIC EFLTKESKLR IYYTTERDEQ GSKINDFFMK SEDLFNEMNW QKKLRAQPFL
     YWCARNMSFW SSISFNLAVL MNLLVAFFYP FKGIRGGTLE PHLSGLLWTA MLISLAIVIA
     LPKPHGIRAL IASTILRLIF SVGLQPTLFL LGAFNVCNKI IFLMSFVGNC GTFTRGYKAM
     IMDVEFLYHL LYLLICALGL FVHEFFYSLL LFDLVYREET LLNVIKSVTR NGRSIILTAV
     LALILVYLFS IVGYLFFKDD FILEVDKLPN ETLLPDRTEP GETMTGEFLY SDVCKAGSSE
     NCSSIIPSDQ VIAEEMEEEN KEHTCETLLM CIVTVLSHGL RSGGGVGDVL RKPSKEEPLF
     AARVIYDLLF FFMVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI CGLERDKFDN
     KTVTFEEHIK EEHNMWHYLC FIVLVKVKDS TEYTGPESYV AEMIKERNLD WFPRMRAMSL
     VSSDSEGEQN ELRNLQEKLE STMKLVTNLS GQLSELKDQM TEQRKQKQRI GLLGHPPPMN
     VNPQQPA
//
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