ID R0LL33_ANAPL Unreviewed; 928 AA.
AC R0LL33;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
DE Flags: Fragment;
GN ORFNames=Anapl_04025 {ECO:0000313|EMBL:EOB06389.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB06389.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; KB742617; EOB06389.1; -; Genomic_DNA.
DR AlphaFoldDB; R0LL33; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF20; ANOCTAMIN-2; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 291..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 368..384
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 450..474
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 494..513
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 669..693
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 723..745
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 828..849
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 3..277
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 280..863
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 890..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 928
FT /evidence="ECO:0000313|EMBL:EOB06389.1"
SQ SEQUENCE 928 AA; 107336 MW; C95FBC08D2A4DC49 CRC64;
MHFRDSKRKV DYVLAYHYRK RLAQHQHGAS SPEPMNRAGS MTVVSNGETR KGRLKLQPDS
GQHIPQELLG AQMIELGPLD ALEEEKRLQR EEYEHNLVAA GLEIEKDAEN KSQGLSFVRI
HAPWQVLSRE AELHKIKMPT KKMYEIKEEG GILKKLNKIW CKLTEPLQPQ VPQENTKMKS
LSYPFSREKI YLYNIRDKDT FFDNATRSRI VHEILKRTST KARNSMGINT LIANNVYDAA
YPLHDGEYEG QNDDMNERKL LYQEWARYGV FYKFQPIDLI RKYFGEKIGL YFAWLGLYTE
FLIPSSVVGI FVFLYGCITI ESDIPSKEMC DQRNAFTMCP LCDKFCDYWN LSSACATARA
SHLFDNPATV FFSIFMALWA TMFLEQWKRL QMRLSYFWDL TGLEEEEEHP RPEYETKLLQ
KKMKNKNTTT EDPNEDEKDK LTWNDRIPGY AANCGLILFM IMLTFSAVFG VIVYRITTAA
ALSFSTNETT RSNVRVTVTA TAVIINLVVI LILDEIYGAV AKWLTEIEVP KTEKAFEERL
ILKAFLLKFV NSYAPIFYVA FFKGRFVGRP GHYVYVFDGY RMEECAPGGC LMELCIQLSI
IMLGKQLIQN NLFEIGIPYV SQPYPLPHFI PTALQTLIDT TTRFKEVLAQ IITHPFPFKR
HPRTMHISLP VIQFGFVTLF VASFPLAPLF ALLNNIIEVR LDAKKFVTEL RRPDTVRAKD
IGIWYNILSG IGKLSVIINA FVIAVTSDFI PRLMYQYAYS QNGTMHGFIN HTLSYFNVSH
LKAGTQPENS PFAQDVLFCR FKDYREPPWS PNQYEFSKQY WAVLSARLAF VILFQNLVMF
LSVLVDWMIP DIPKDISEQI KKEKSVLVDF FLKEEHEKLK LIESFITRDK HKQKSGTKDQ
KSRSASFCQF DRSQKGSVAS FSSQHTEV
//
