ID R0LWJ8_ANAPL Unreviewed; 1453 AA.
AC R0LWJ8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=P-type Cu(+) transporter {ECO:0000256|ARBA:ARBA00012517};
DE EC=7.2.2.8 {ECO:0000256|ARBA:ARBA00012517};
DE Flags: Fragment;
GN ORFNames=Anapl_11944 {ECO:0000313|EMBL:EOB04853.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB04853.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
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DR EMBL; KB742740; EOB04853.1; -; Genomic_DNA.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR CDD; cd00371; HMA; 6.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 6.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR NCBIfam; TIGR00003; copper ion binding protein; 5.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 6.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00942; CUATPASEI.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 6.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 5.
DR PROSITE; PS50846; HMA_2; 6.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00022796}.
FT TRANSMEM 632..651
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 671..693
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 705..731
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 737..758
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 901..925
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 945..968
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1317..1339
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1345..1365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 37..103
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 122..188
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 234..300
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 334..400
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 466..532
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 542..608
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 422..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOB04853.1"
FT NON_TER 1453
FT /evidence="ECO:0000313|EMBL:EOB04853.1"
SQ SEQUENCE 1453 AA; 156451 MW; 8333D5495BAC5173 CRC64;
SPPSCALEPT MKQHFAFDNM GYEESFETLP SPSSQEHTVA VRVVGMTCQS CVQSVEGRIS
KVKGVVSIKV SLEQNNALVK YLQSEISPEQ ICQEIQDMGF DANVAEERLT PASVSLPCSR
EAVIKLRIEG MTCQSCVTSI EGKMKKLHGV AKIKVSLANQ EAIIAYQPYI IQPEELKSHI
SSLGYNCTIK SKSAPLKLGV LDLGRLQSTD PKETPASLES DGLEPQAAKM GGTATVAVRI
EGMHCKSCVR NIEGNISSLP GVQSINVSLE RKCAVVRYSP NLITLSALQQ AIESLPPGNF
KVRLPNDSEA NNQVSPPPAL PCGLAGEPLD DTTCTAVIRI DGMTCNSCVQ SIEGTISQRQ
GVQHVAVSLA GKTGTIHYDP AVTNGEDLRA AIEDMGFDAS VLTASVCSLY CAFIQDTGTG
EHKHRPGASD AAVQARAPES PHQDRASDAL LDGPHLDGPN QPGEAKKCFL QITGMTCASC
VSAIERKLQK EDGIVSVLVA LMAGKAEIKY KPEFIQPLEI AQLIQNLGFE ATVIEDHAET
EGNVELLITG MTCASCVHNI ESKLMRTNGI FYASVALATC KAHIQFDPEI TGPRDIIKII
EEIGFHASVS RRVPNAHNLD HKKEIQQWRK SFLCSLVFGI PVLILMIYML IPDGGHHGSM
VLEQNLIPGL SILNLLFFVL CTFVQFLGGW YFYLQAYKSL KHKTANMDVL IVLATTIAYV
YSCVILMVAI IEKAEKSPVT FFDTPPMLFV FIALGRWLEH IAKSKTSEAL AKLISLQATE
ATVVTLGPDH SIIREEQVAV ELVQRGDIVK VVPGGKFPVD GKVIEGSSMA DESLITGEAM
PVTKKPGSTV IAGSINAHGS VLVNATHVGN DTTLAQIVKL VEEAQMSKAP IQQLADRFSG
YFVPFIIIIS TVTLLVWITI GFIKFDIIQK YFPNQNKDVT KAELILRFAF QTSITVLSIA
CPCSLGLATP TAVMVGTGVA AQNGILIKGG KPLEMAHKIK TVMFDKTGTI TCGVPKVMRV
LLLGDTAVLS LKKVLAVVGT AEASSEHPLG VAVTKYCKEE LGTQSLGYCT NFQAVPGCGI
SCKVGGVEAV LGMAEEGLVQ PETVVLGHNV SGMSPFCKSL IFLFSLHEGP SASHVYSVLI
GNREWMRRNG LHIANDVNDA MTDHETKGQT AVLVAIDGAL CGMIAIADTV KQEAALAVHT
LKNMGIDVVL ITGDNRKTAK AIATQVGIKK VFAEVLPSHK VAKVQELQSE RRKVAMVGDG
VNDSPALARA DIGIAIGTGT DVAIEAADVV LIRNNLLDVV ASIHLSKRTV RRIRINLILA
LIYNLLGIPI AAGVFMPVGL VLQPWMGSAA MAASSVSVVL SSLQLKYKKP DTESYEAQAQ
GRMKPLTPSQ ISVHIGMDDR RRDSSRPAPW DQISQVSLSS LTSDKLPRHN GFFEEEGDKW
SLLMNGRDEE QYI
//
