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Database: UniProt
Entry: R0LY36_ANAPL
LinkDB: R0LY36_ANAPL
Original site: R0LY36_ANAPL 
ID   R0LY36_ANAPL            Unreviewed;       136 AA.
AC   R0LY36;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 72.
DE   RecName: Full=Histone H3 {ECO:0000256|RuleBase:RU004471};
DE   Flags: Fragment;
GN   ORFNames=Anapl_01038 {ECO:0000313|EMBL:EOB06755.1};
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB06755.1, ECO:0000313|Proteomes:UP000296049};
RN   [1] {ECO:0000313|Proteomes:UP000296049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23749191; DOI=10.1038/ng.2657;
RA   Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA   Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA   Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA   Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA   Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA   Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA   Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA   Rao M., Pitel F., Wang J., Li N.;
RT   "The duck genome and transcriptome provide insight into an avian influenza
RT   virus reservoir species.";
RL   Nat. Genet. 45:776-783(2013).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC       {ECO:0000256|ARBA:ARBA00002001}.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA. {ECO:0000256|RuleBase:RU004471}.
CC   -!- SIMILARITY: Belongs to the histone H3 family.
CC       {ECO:0000256|ARBA:ARBA00010343, ECO:0000256|RuleBase:RU004471}.
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DR   EMBL; KB742585; EOB06755.1; -; Genomic_DNA.
DR   RefSeq; XP_005012229.1; XM_005012172.2.
DR   RefSeq; XP_005012232.1; XM_005012175.2.
DR   RefSeq; XP_012948124.1; XM_013092670.1.
DR   AlphaFoldDB; R0LY36; -.
DR   SMR; R0LY36; -.
DR   GeneID; 101798542; -.
DR   KEGG; apla:101798542; -.
DR   HOGENOM; CLU_078295_4_0_1; -.
DR   OMA; ANDCAIH; -.
DR   OrthoDB; 4405952at2759; -.
DR   Proteomes; UP000296049; Unassembled WGS sequence.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR000164; Histone_H3/CENP-A.
DR   PANTHER; PTHR11426; HISTONE H3; 1.
DR   PANTHER; PTHR11426:SF265; HISTONE H3.2; 1.
DR   Pfam; PF00125; Histone; 1.
DR   PRINTS; PR00622; HISTONEH3.
DR   SMART; SM00428; H3; 1.
DR   SUPFAM; SSF47113; Histone-fold; 1.
DR   PROSITE; PS00322; HISTONE_H3_1; 1.
DR   PROSITE; PS00959; HISTONE_H3_2; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW   Chromosome {ECO:0000256|RuleBase:RU004471};
KW   DNA-binding {ECO:0000256|RuleBase:RU004471};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Nucleosome core {ECO:0000256|RuleBase:RU004471};
KW   Nucleus {ECO:0000256|RuleBase:RU004471};
KW   Reference proteome {ECO:0000313|Proteomes:UP000296049}.
FT   DOMAIN          1..132
FT                   /note="Histone H2A/H2B/H3"
FT                   /evidence="ECO:0000259|Pfam:PF00125"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         136
FT                   /evidence="ECO:0000313|EMBL:EOB06755.1"
SQ   SEQUENCE   136 AA;  15388 MW;  6FD8508EA50A0EEC CRC64;
     MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE
     LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEASEAY LVGLFEDTNL CAIHAKRVTI
     MPKDIQLARR IRGERA
//
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