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Database: UniProt
Entry: R1BG12_EMIHU
LinkDB: R1BG12_EMIHU
Original site: R1BG12_EMIHU 
ID   R1BG12_EMIHU            Unreviewed;       900 AA.
AC   R1BG12;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   16-JAN-2019, entry version 31.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   ORFNames=EMIHUDRAFT_471092 {ECO:0000313|EMBL:EOD08272.1};
OS   Emiliania huxleyi (Pontosphaera huxleyi).
OC   Eukaryota; Haptophyceae; Isochrysidales; Noelaerhabdaceae; Emiliania.
OX   NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD08272.1};
RN   [1] {ECO:0000313|EMBL:EOD08272.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD08272.1};
RG   DOE Joint Genome Institute;
RA   Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F.,
RA   Mayer C., Miller J., Allen A., Bidle K., Borodovsky M., Bowler C.,
RA   Brownlee C., Claverie J.-M., Cock M., De Vargas C., Elias M.,
RA   Frickenhaus S., Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A.,
RA   Herman E., Iglesias-Rodriguez D., Jones B., Lawson T., Leese F.,
RA   Lin Y.-C., Lindquist E., Lobanov A., Lucas S., Malik S.-H.B.,
RA   Marsh M.E., Mock T., Monier A., Moreau H., Mueller-Roeber B.,
RA   Napier J., Ogata H., Parker M., Probert I., Quesneville H., Raines C.,
RA   Rensing S., Riano-Pachon D.M., Richier S., Rokitta S., Salamov A.,
RA   Sarno A.F., Schmutz J., Schroeder D., Shiraiwa Y., Soanes D.M.,
RA   Valentin K., Van Der Giezen M., Van Der Peer Y., Vardi A., Verret F.,
RA   Von Dassow P., Wheeler G., Williams B., Wilson W., Wolfe G.,
RA   Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA   Glockner G., John U., Richards T., Worden A.Z., Zhang X.,
RA   Grigoriev I.V.;
RT   "Genome variability drives Emilianias global distribution.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblProtists:EOD08272, ECO:0000313|Proteomes:UP000013827}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCMP1516 {ECO:0000313|EnsemblProtists:EOD08272,
RC   ECO:0000313|Proteomes:UP000013827};
RX   PubMed=23760476; DOI=10.1038/nature12221;
RA   Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA   Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA   Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA   Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D.,
RA   de Vargas C., Verret F., von Dassow P., Valentin K., Van de Peer Y.,
RA   Wheeler G., Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G.,
RA   John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.,
RA   Allen A.E., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA   Cock J.M., Elias M., Gladyshev V.N., Groth M., Guda C., Hadaegh A.,
RA   Iglesias-Rodriguez M.D., Jenkins J., Jones B.M., Lawson T., Leese F.,
RA   Lindquist E., Lobanov A., Lomsadze A., Malik S.B., Marsh M.E.,
RA   Mackinder L., Mock T., Mueller-Roeber B., Pagarete A., Parker M.,
RA   Probert I., Quesneville H., Raines C., Rensing S.A.,
RA   Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA   van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA   Wurch L.L.;
RT   "Pan genome of the phytoplankton Emiliania underpins its global
RT   distribution.";
RL   Nature 499:209-213(2013).
RN   [3] {ECO:0000313|EnsemblProtists:EOD08272}
RP   IDENTIFICATION.
RG   EnsemblProtists;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675,
CC         ECO:0000256|SAAS:SAAS01116863};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; KB869031; EOD08272.1; -; Genomic_DNA.
DR   RefSeq; XP_005760701.1; XM_005760644.1.
DR   EnsemblProtists; EOD08272; EOD08272; EMIHUDRAFT_471092.
DR   GeneID; 17254423; -.
DR   KEGG; ehx:EMIHUDRAFT_471092; -.
DR   KO; K12309; -.
DR   Proteomes; UP000013827; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 3.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000013827};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013827};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    857    877       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       22    384       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      660    759       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
SQ   SEQUENCE   900 AA;  97368 MW;  917203D87744FFF9 CRC64;
     MDLGALFGGS SAPARLLIER DQFVLDGQNF TVRAGCVHYF RVHPDLWEDR LARIAALGLN
     AVQTYVPWNY HQAWNASSLG PARVDLDSPS RDLPRFLRLA HGLGLRVVLR PGPYVCGEFE
     FGGLPAWLLR DGPIELRTDA EPYMGHVERW WGELLPRLRR EGLMLDDGGP VMLVQIENEY
     GHFGDVSEVE ADRRYLERLA DLARRHLGDG AQLFTSDPDD LAKLTRGTLS PSASRLGSEE
     RRPPTSRSER RRGPHALPPP SRRRSSQVLT TVDSCDVPED AWAAQRSFNP PGRSPFFCSE
     LWVGWFAHWG EPARPNLAAQ RARDVAERLR RVLAVNGGTG SVSLYMAHGG TSFGWWAGAN
     TADGMYLPDT PSYDYGAPIG EGGGHGLDEA GGDKYAALQS VLLEAPSGSG SSVPSSSPSA
     SRPPSPPAEP QPLREEPPPP RRLSSTVEVE LPEAVRLMEA ETLAALSGGG RCCDELPLPM
     EEVGCDYGIV VYETELPAGG GGPLQVSRLR DRLLAFVDGE FVGRMYRQQG WGRADPKGLL
     MPPPRPYPRT LRLLVENLGR VGFVDLPWFS RTFLLDQRKG ILGGVWLNGT LLNRTGPDGQ
     AGWRTHCLPF DDAQLDVLRR LPARQPSGLL DTAGSVALGA GSVALDAGSV AVSVAGAMLH
     LAQGSDRDSP PSLPSSLPSS QPRSAATATF YRGAFELPSA DAGADAWLAL GGGWAHGTAW
     VNGWHLGRYW LPEGPQRSLY VPGPLLREGG NELLLLSLDV AEAEADGQPR WARLYPSPNH
     TGARSAPQET AAASSRQLQI YSYAAAYSAT KLTSANARHA VVDAFSHLEG LLSLGSKIIR
     LRAPAEPAAQ RPSAAPIVAA IAAAGALLAL VAAAYVFRAG RLRRPWRRRD RALARRFFLV
//
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