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Database: UniProt
Entry: R1BI32_EMIHU
LinkDB: R1BI32_EMIHU
Original site: R1BI32_EMIHU 
ID   R1BI32_EMIHU            Unreviewed;      1032 AA.
AC   R1BI32;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=EMIHUDRAFT_216860 {ECO:0000313|EMBL:EOD09042.1};
OS   Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC   Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC   Noelaerhabdaceae; Emiliania.
OX   NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD09042.1};
RN   [1] {ECO:0000313|EMBL:EOD09042.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD09042.1};
RG   DOE Joint Genome Institute;
RA   Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA   Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA   Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA   Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA   Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA   Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA   Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA   Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA   Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA   Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA   Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA   Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA   Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT   "Genome variability drives Emilianias global distribution.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000013827}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX   PubMed=23760476; DOI=10.1038/nature12221;
RA   Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA   Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA   Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA   Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA   Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA   Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA   Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA   Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA   Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA   Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA   Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA   Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA   Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA   van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA   Wurch L.L.;
RT   "Pan genome of the phytoplankton Emiliania underpins its global
RT   distribution.";
RL   Nature 499:209-213(2013).
RN   [3] {ECO:0000313|EnsemblProtists:EOD09042}
RP   IDENTIFICATION.
RG   EnsemblProtists;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
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DR   EMBL; KB868759; EOD09042.1; -; Genomic_DNA.
DR   RefSeq; XP_005761471.1; XM_005761414.1.
DR   STRING; 2903.R1BI32; -.
DR   PaxDb; 2903-EOD09042; -.
DR   EnsemblProtists; EOD09042; EOD09042; EMIHUDRAFT_216860.
DR   GeneID; 17255185; -.
DR   KEGG; ehx:EMIHUDRAFT_216860; -.
DR   eggNOG; KOG2108; Eukaryota.
DR   HOGENOM; CLU_294139_0_0_1; -.
DR   OMA; EYQDNSE; -.
DR   Proteomes; UP000013827; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Helicase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000013827}.
FT   DOMAIN          90..518
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          519..896
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          274..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          746..786
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         111..118
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1032 AA;  113530 MW;  F91F8050CCDC636B CRC64;
     MPKRKPEGAE FDLPLPDASN SLAPQQRLLR LEFERFCASR VGAGGVVGAS GDDGGENSSA
     DGRHLASILQ REAAKFNEGD DELLCAALDA TCEAHSAAVA DSTASELSVR AGAGTGKTHT
     MIQRAVRLVR LGVPPNCVLM VTFSVKAAEE LCSRVGHAFA ALGVPPRLLP VGKTFHALAF
     FWVRRYWRAL ELGAAPAPLT GDAGVRKFMQ RVLEEQVAEK RLEWCVAALR KHLLRPGGAD
     ADGAPPSWEE VLAFARQSLP ASWRRACEAA EREVPFDEAQ AAPARKKRRG GRDAADVAAE
     EEEARARRAE LEAARMVARR AHVYLELRGA QRRSSRARAP PAQRATGEGE EEEGGPMPPG
     EDPIARLWLG ASKKERRDKV AFYLELVRRG RQQRQGYSEY LKDDADVWRR YDAMQRREGR
     LDFDAMLLHF HRLLGEHEGA RRAFHAAHSH LIVDEYQDNS EMQAKLLELM VNQADPQVTV
     VGDDDQCIYC FRGAEPGNFS RLPQRYEHCT LVDNYRSTAN ILRVAHVLLE ECARREAKTL
     APTRETGAPV ELWKVATPAE QASELVRAMR ARHEEGVPWG EMACLFRCFK AGEMGSLHKP
     LQQELSLRRV PYTLLGGKGL FELAAVLDAL AYLRLAALGS GEHDDEAFVR ILNRPKRRLP
     EESVLRVVEH QRRALVEARR GLPVGLEAAA RQMVASGVGV KKSQRASLGS LLALLDELRD
     ACVMAELPAM LLRVWSAAGL DAMHQRKERS QRRALAPLQG TARDRGDEGV ADAGGQGAGG
     GDSSAMRLPS EVSSLVEVAT AFSTEYAARE RAAAGSERSL FALCRTYVLD HAAELQLSAL
     PDCVVDELFA SRGRGRSVMR AFLTEVAMRS SAADAQDAAA EGSSKVSIST IHRAKGLEWC
     DVYVPFLNDG LLPMGYREET GNTAQRHKPQ CAARRANGHC DLNCARAYRE ADAHARGTPE
     ERHADEERRL AHVAATRAKD RLVFITVQLR REGAFAARNA MEPSPYERSL RAALPEETLV
     TRVRGELQDA EE
//
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