ID R1CUH2_EMIHU Unreviewed; 727 AA.
AC R1CUH2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN ORFNames=EMIHUDRAFT_107093 {ECO:0000313|EMBL:EOD05945.1};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD05945.1};
RN [1] {ECO:0000313|EMBL:EOD05945.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD05945.1};
RG DOE Joint Genome Institute;
RA Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT "Genome variability drives Emilianias global distribution.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [3] {ECO:0000313|EnsemblProtists:EOD05945}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; KB869934; EOD05945.1; -; Genomic_DNA.
DR RefSeq; XP_005758374.1; XM_005758317.1.
DR PaxDb; 2903-EOD05945; -.
DR EnsemblProtists; EOD05945; EOD05945; EMIHUDRAFT_107093.
DR GeneID; 17252094; -.
DR KEGG; ehx:EMIHUDRAFT_107093; -.
DR eggNOG; ENOG502S7BT; Eukaryota.
DR HOGENOM; CLU_381051_0_0_1; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR Pfam; PF13676; TIR_2; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000013827}.
FT DOMAIN 340..422
FT /note="TIR"
FT /evidence="ECO:0000259|Pfam:PF13676"
FT REGION 667..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 727 AA; 76870 MW; 08DE5EB0E55EEB45 CRC64;
MSVAVIVLST AAATHRAIIS CPTAFVNLSV SCVRAGGEWR AIDRLANPSR VPASFHFTDS
SLLEVETGEL ERASQVGTCQ PATADGHAVF EPEASKIEVA KGHHPTKLTE IMPVNVPESW
AAGQLRKLVE TGLGLVETGL VCAGSLLLGR SRVASLGVSV THVRLAAAAL LVGRVAAQNA
CGECVACKCV ACVNEIPSGC YPYDPTGDMG PPNAEVCIEQ AGGIDCSVVP RAPPYPPSPP
PSPLLPGGYF ITGPCSLTDG GSCAASPNYP LSYGNNEMCT ISGVPPVGLE VVAFDVESGF
IYDYLTVNGV RRALMRLVSS KREPMREGIT LAEGQQWHLF LSHVWSTGQD AVAVIKNELQ
QFLPGCEIFL DVDDLKNIGE LEAYIGRSQV VLCFLSRGYL RSTNCLREVR AALEMGKPLV
LVHEADPAKG GGTLAELRSE CPEELQAAIF DAGWPMVVWH RIEDFQHVSL KVIAEALLLK
TPKYAGEDAL PLCIPGELRA DGLAFPKPVV LWASTVNDGA RDLANAVVAA VAGSISVTDA
PPSRLSSLPR ASDSGGDEAT HMLLYLKWST WAGDGAEALA EQVRAAREAK LPIVMAHEND
AALGGCIFGR FFEVTPRDLI ADGLYDDLAV GCHEDPHRQV SIALLAQALG ATKQTAQSRV
RRGTALARTA QTRGSSSKTE LQEQSVGLHG MPGELPALGC RDDSVGDELV AEGCDEPGAH
AQMSQIV
//
