ID R1EAE6_EMIHU Unreviewed; 1107 AA.
AC R1EAE6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN ORFNames=EMIHUDRAFT_469461 {ECO:0000313|EMBL:EOD23680.1};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD23680.1};
RN [1] {ECO:0000313|EMBL:EOD23680.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD23680.1};
RG DOE Joint Genome Institute;
RA Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT "Genome variability drives Emilianias global distribution.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [3] {ECO:0000313|EnsemblProtists:EOD23680}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; KB865553; EOD23680.1; -; Genomic_DNA.
DR RefSeq; XP_005776109.1; XM_005776052.1.
DR PaxDb; 2903-EOD23680; -.
DR EnsemblProtists; EOD23680; EOD23680; EMIHUDRAFT_469461.
DR GeneID; 17269224; -.
DR KEGG; ehx:EMIHUDRAFT_469461; -.
DR HOGENOM; CLU_009515_0_0_1; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR Pfam; PF13676; TIR_2; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000013827};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 421..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 681..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 732..816
FT /note="TIR"
FT /evidence="ECO:0000259|Pfam:PF13676"
FT REGION 43..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 118427 MW; 00F68E204A44FE07 CRC64;
MLKLEFVPAA GDKLVLKLSP PPPLADKQAS LAADNTAVVD SDGGNAVGIP SEPVSLKDGI
DTGTGGTCTA NTGTGNVPSE GEPAGSLAGV HFAGVSLDAV PEAFTVDDPA GAKAVGIPPE
SEPSPLKDGI DASSGNVAGG SSPMKSFAKV GIVPADDGRI TIVISESVSP SLLGAKACGV
KDITVAKSGT EDVLKKDPAA EKAPDAGAVD SDKAKAMFAT HPPAVFWSKF TRPTGPPTAP
TGAVKGALKK DIPAATSGAE ACVDETGAIK NPALKPATEV ATALKPAEAG GAPLPSIKEF
PEEKKPAATA ASAWYCGDTR VLQAGTGLVL YRAIARAEAW GRLRARLDIC ESQVGFQPKF
KILVSFYQIA ATLGPVYGVR LHEDFTRWTD FMDAISLDLL GLTYPDACIG SMGDRLLLAG
LWPIFSIMLG GAALACCALA EWLLSGRADA LQRDLVRATL RRLLYWAILV AYLVLPSVSR
SIFKARQCES FNVDDLTGDR RSYLVADLDV LCSADDDEYS GLDAYFWAFF VLWPVLVPLA
FLALLLSIRS EVQAQRVRAT ARASRFLWRD YDPRFLFWEV VDLGRKLFLA SLVLFIQTDD
GSSKLLRLLV ASVVSALYLA ALALARPFKR DDDLYLACTA NLLLACCFTS GMVIQLCESA
AYEDMCKALV GFESARGASE FVIALTAAML AASLLVVLFK TVSAVRMPTI RLSSSGRPPV
LELSPECHFH GFISHCWGTG QDQTHTVVRQ LQLLLPGVRI WLDVDNLEDV GRLEESVRDA
TTFLVFLSAG YFKSFNCRRE LYAALGSNRP FIPIQEADVD KGGASIEALK AECREHCVEV
APPGHPSYSG PDEMLARVFE ATTPIVWVRV NAFQLESLKA VALRMLLHSP YYASRPAELA
GGVMVPRQAG PVAFSGPVTI LVCRDNEDAV GIARELNTAA REGRGSTASA ETVTIRDAEE
ALEGVNAAPL SGHVVCLLYL NDKTFLDAGG AVARLVQAAM DRRIAIAMVH EQDPTCGGVP
FRNFFQQTPQ VLLQPPYKLF DTVAVPLYPA PAHRTVSRRL ALCSMGAVPC DAGPLQRRWQ
LLRRRIAVAR LVRRRPAESR QQPVVQP
//
