ID R1EZM3_EMIHU Unreviewed; 1219 AA.
AC R1EZM3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Lipoxygenase domain-containing protein {ECO:0000259|PROSITE:PS51393};
GN ORFNames=EMIHUDRAFT_205326 {ECO:0000313|EMBL:EOD26334.1};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD26334.1};
RN [1] {ECO:0000313|EMBL:EOD26334.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD26334.1};
RG DOE Joint Genome Institute;
RA Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT "Genome variability drives Emilianias global distribution.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [3] {ECO:0000313|EnsemblProtists:EOD26334}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; KB865188; EOD26334.1; -; Genomic_DNA.
DR RefSeq; XP_005778763.1; XM_005778706.1.
DR STRING; 2903.R1EZM3; -.
DR PaxDb; 2903-EOD26334; -.
DR EnsemblProtists; EOD26334; EOD26334; EMIHUDRAFT_205326.
DR GeneID; 17271879; -.
DR KEGG; ehx:EMIHUDRAFT_205326; -.
DR HOGENOM; CLU_270899_0_0_1; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR GO; GO:0034440; P:lipid oxidation; IEA:InterPro.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR000907; LipOase.
DR InterPro; IPR013819; LipOase_C.
DR InterPro; IPR036226; LipOase_C_sf.
DR PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR PANTHER; PTHR11771:SF153; LIPOXYGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00305; Lipoxygenase; 1.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF48484; Lipoxigenase; 1.
DR PROSITE; PS51393; LIPOXYGENASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000013827};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 884..1112
FT /note="Lipoxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51393"
SQ SEQUENCE 1219 AA; 130463 MW; 213EA64E8A0DDA70 CRC64;
MRATRHLLDA HLLDGTLAVS RARQRRRSHM PSCCFSALVI SGTSAILLAG ALSSLDGALK
FARLDLALRS SLVDTAGADL EAGLPTAARL ALLAAFEVPV AVATGMDPAA HLDVYVRASG
RQPFLFGKGI AVPGYDDVST LVSSPQQERR AMVLAHPVLI ADPVPPACMG GGTLIYLSTG
AKHTALRRAI GRAVTGFALK RGRGPPLLFP RGAAPAEWDS RAVRETAPLL GAALDSQANA
TLETRLALKA AVLASPLGGR LRKANRADKL DADELAQQVA DGLLFAGGYG TTHLTLAALE
RISSDPALYA DPDAFLVESA RLDPPVTSVS AIAPKGGQQL QGPGGGQLRV AQGVPMQLLL
SHANRDPAVF ERPYAFDPSR RNLDKVLSWN GVDAAGSCDY SASDRPSEDL ELRNEHDDEA
MYAYYGAGLV NIVLGVLALI VLGWFCLSQR LAFGALYVKG DAGIIRVQSW LGLLHYLGQA
IAAFSWLRLH AVVTHADDAR ARAESASALR LCFGVMAIFV GAFAVFGTAA ACVLFVPAAA
KSWIAIAMFW WRHGGVLVLA ACAFIAFWVG QVIAEQRGMS LIDYEAGSGI GVTLLARGLL
GAEAAPHAWK YEVFARGFLA PSVYFAAAAH IDRVQGRGLG RAYPSELFMR RALRFKHSAP
VLLALALAAI HSFAIPRSFG DITGCGEGGG EAAGPECAVD PTGGLDQYTK VYFSIIHLLD
DGSQPGPSFV QAPNRTVQPL PKEQVVPGLV LPSYDEDEGL VTSRALANQA FSGYVKDGRL
YPLEDLDLPW PEKDGAIEAL MGRLSGSLAP AELYDYDANI GGDSLIGDAG NPDFPPPASR
RWFRTHSLEM CARHADFTYL APLTVRPGFE RYGAKATFDA AARPVSIWWS HGEKEVRPDD
AAWTHAKFAF RSSLLTGVTL KDHLAATHLT IAATLVSASR DHLPATHPLR RLLKPFTYRT
IALSLLHHTV ALDAAGLEAG FAFAFNRTRD TFDPANPARF LEYPLEYPLS SAAECAATPP
SSQAACADEA DELAAFAADG TRYRAAVREY VGRYVGIYYA DDAAVGSDVV LASFWAALVA
HFPRIPPLSS REALVEVLTG FVFHVTAGHR HVGAAYSAVK DPRYAGAKIR PGRDMSDVQA
AVQVLAIALV TGFKQPMLLG DYSHVFLRDG HRNATRALWS DFQAKLLQVS AEVDERNRGP
RRFKVRAFDP REMATSVSI
//
