ID R1F274_9GAMM Unreviewed; 631 AA.
AC R1F274;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Acetyl-CoA synthetase {ECO:0000313|EMBL:EOD54033.1};
DE EC=6.2.1.1 {ECO:0000313|EMBL:EOD54033.1};
DE Flags: Fragment;
GN ORFNames=G113_16405 {ECO:0000313|EMBL:EOD54033.1};
OS Aeromonas molluscorum 848.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=1268236 {ECO:0000313|EMBL:EOD54033.1, ECO:0000313|Proteomes:UP000013526};
RN [1] {ECO:0000313|EMBL:EOD54033.1, ECO:0000313|Proteomes:UP000013526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=848 {ECO:0000313|EMBL:EOD54033.1,
RC ECO:0000313|Proteomes:UP000013526};
RX PubMed=23788549;
RA Spataro N., Farfan M., Albarral V., Sanglas A., Loren J.G., Fuste M.C.,
RA Bosch E.;
RT "Draft Genome Sequence of Aeromonas molluscorum Strain 848TT, Isolated from
RT Bivalve Molluscs.";
RL Genome Announc. 1:E00382-13(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOD54033.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQGQ01000140; EOD54033.1; -; Genomic_DNA.
DR RefSeq; WP_005906750.1; NZ_AQGQ01000140.1.
DR AlphaFoldDB; R1F274; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000013526; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR HAMAP; MF_01123; Ac_CoA_synth; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF243; ACETYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EOD54033.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 24..81
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 83..466
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 530..608
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT NON_TER 631
FT /evidence="ECO:0000313|EMBL:EOD54033.1"
SQ SEQUENCE 631 AA; 69430 MW; 6CF9E71883A40738 CRC64;
MSEHKVYPVK SHISQDALLD KAGYEAMYQA SVQDPDAFWG EQGKILDWMT PYTKVKNSSY
DPGHVSIKWF EDGQLNVSAN CLDRHLAQRG DKVAIIWEGD NPAEDRKLTY RELHGEVCKF
ANVLKAQGVK RGDVVCLYMP MVPEAAVAML ACTRIGAVHS IVFGGFSPEA LAGRIIDSGS
SIVITADEGL RGGRAVPLKK NVDDALANPE TRIEKVIVLK RTGGQVAWHS ARDIWWHDAM
ATASSDCPPE AMNAEDPLFV LYTSGSTGKP KGVLHTTGGY LVYAALTFKY VFDYHEEDIY
WCTADVGWVT GHSYLVYGPL ANGATTIMFE GVPNYPATNR MSQVVDKHNV SILYTAPTAI
RALMAKGKEA IEGTSRSSLR IMGSVGEPIN PEAWEWYYRT IGDERCPIVD TWWQTETGGI
LISPLPGVTD LKPGSATRPF FGVQPALVDN LGEVLEGATE GNLVITDSWP GQMRTVFGDH
ERFEQTYFST FPGRYFTGDG ARRDEDGYYW ITGRVDDVLN VSGHRMGTAE IESALVAHPK
IAEAAVVGVP HEIKGQGIYA YVTLIAGEEP SRELHKEVKE WVRKEIGAIA TPDVIHWAEG
LPKTRSGKIM RRILRKIATG ETDSLGDIST L
//
