ID R1F5P0_EMIHU Unreviewed; 1226 AA.
AC R1F5P0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=TNFR-Cys domain-containing protein {ECO:0000259|PROSITE:PS50050};
GN ORFNames=EMIHUDRAFT_201913 {ECO:0000313|EMBL:EOD34240.1};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD34240.1};
RN [1] {ECO:0000313|EMBL:EOD34240.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD34240.1};
RG DOE Joint Genome Institute;
RA Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT "Genome variability drives Emilianias global distribution.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [3] {ECO:0000313|EnsemblProtists:EOD34240}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; KB864346; EOD34240.1; -; Genomic_DNA.
DR RefSeq; XP_005786669.1; XM_005786612.1.
DR PaxDb; 2903-EOD34240; -.
DR EnsemblProtists; EOD34240; EOD34240; EMIHUDRAFT_201913.
DR GeneID; 17279511; -.
DR KEGG; ehx:EMIHUDRAFT_201913; -.
DR HOGENOM; CLU_253752_0_0_1; -.
DR OMA; MFLECEE; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11319; G PROTEIN-COUPLED RECEPTOR-RELATED; 1.
DR PANTHER; PTHR11319:SF35; OUTER MEMBRANE PROTEIN PMPC-RELATED; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000013827};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 639..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 849..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 369..420
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 369..420
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
SQ SEQUENCE 1226 AA; 132993 MW; 8550C5CA80D12272 CRC64;
MTDIYLQPGA NVRLSQSLVL DGVDVTIRSS GSTTGATIDG TDALDSLFIL KNKATLWLEG
LVLANCQAEA DGGAVRMDDS DVSLRDVRIQ DCSAANSGGA IYAARGSLRL ESVEITRCSA
ETGTEGENAQ GLGGAIRIVK VREVELSEVN ITGCSAVKGG ALHIDGGTES ETTLNRVRLA
DSTATEEGGL VYIVSGRLTL ENGTLLESGT ASQGSSIAFS GAPEVSYRLP LPPGYWIPHS
RCEIYRQLPA DCADDVCRGL FDKCKTETDA QNDECKQFPV AFVQPCNWEA TPALLGVSLY
QVPTSALDVD LPYACAPGIL GSSDADDQKS AFCAGLCPVG QRCPEAATTE PRPCTEGNFC
PAGTSVPRPC PEGSYSAATN LTKEDECTQC PVGFTCPAGS TVPDPCNDGT TTYGQGSTAC
DVCDEDFFLV LGEAQASTKA CKSCPAPPSS PQGGVVSFTC GVDTRIGALY WSPCRGGVDS
SEDGNALCHP FYEGPKCEVC TNTTDNGIRY FLNSKARCQP CDRPAESVML LVGLLFTAGA
LGLGTLKVIR SSWVPSGKVA RALVLMGRRM ALLWKRAGML CKTKQLINLF QVVAVVPAVY
EVELPPQLSE WANLFNAVDI FDLDLFLPPA CYGSYLTRLI AWGFLPFAPI LLATLGSCAW
ELASSASLTR AALWRGLLGA LPLIVILQFL LVTSTSTRIL RTFNCIEFPT RDAVLPGGQE
PYRAYLADDL SLDCSTPEYA TVKRWAYVLL FVWPIGAPLL YLGLLLASRR DIMTRQSTPL
LRATDFLWRD YEDSAFYWEP LDLVRKLTLT GFGSKQLRVI IALLVSMLFL TLQYVLSPYK
RTLDGRLSMF ANIGLVLVYL ATLTINSCSL LETDTQTCGE FGLDQLELAT IFLSFTTALL
GIGLTLVLWL YTAASRAPTF RLVSSGREPL RDGRTLTEGM RWHLFLSHIW STGQDAAAVI
KNQLRLLLPG VEVFLDVDDL EGIAALEEYI SNSRVVLLFL SRGYLRSVNC QREVRAALAN
NKPIVLVQEV DPEKGGGALA ELRAECPAEL QNGVFDNRQP IPWHRIREFQ LVSLKLIAEA
TLLQTPRYCG KSNLPLYLPG LLDKQESQAT NALQWLSRRV SSNSINRDGS NGEATHMLLY
LNSSTWSDEL LAKQVTAARA ARLPIIMAHE RDPARGGCLF ARMFEVTPQQ LIVDGLYKNL
ARSCFPDPHR KARGTRVLFS APKSLS
//
