ID R1FL69_EMIHU Unreviewed; 638 AA.
AC R1FL69;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=PI3K/PI4K catalytic domain-containing protein {ECO:0000259|Pfam:PF00454};
GN ORFNames=EMIHUDRAFT_455634 {ECO:0000313|EMBL:EOD34074.1};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD34074.1};
RN [1] {ECO:0000313|EMBL:EOD34074.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD34074.1};
RG DOE Joint Genome Institute;
RA Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT "Genome variability drives Emilianias global distribution.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [3] {ECO:0000313|EnsemblProtists:EOD34074}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00008941}.
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DR EMBL; KB864358; EOD34074.1; -; Genomic_DNA.
DR RefSeq; XP_005786503.1; XM_005786446.1.
DR STRING; 2903.R1FL69; -.
DR PaxDb; 2903-EOD34074; -.
DR EnsemblProtists; EOD34074; EOD34074; EMIHUDRAFT_455634.
DR GeneID; 17279345; -.
DR KEGG; ehx:EMIHUDRAFT_455634; -.
DR eggNOG; KOG2381; Eukaryota.
DR HOGENOM; CLU_445822_0_0_1; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR InterPro; IPR044571; P4KG1-8.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR PANTHER; PTHR45800; PHOSPHATIDYLINOSITOL 4-KINASE GAMMA; 1.
DR PANTHER; PTHR45800:SF11; PI3K_PI4K CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000013827}.
FT DOMAIN 203..405
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|Pfam:PF00454"
FT REGION 67..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 68233 MW; 4EE22F01B66E3BC2 CRC64;
MSSAGKTSVK AKDANLVGGG SSLHFTTIHT PRRRRLDFGL AAHTFQHSSV APRSGFGWTK
ARAPARMQAR GARRVEERSA DNAYSRSARH KATSHIRLLV QPGAHRLRVR AWCSAIDVKQ
RLRDACGVPV GFIRLFHGPR ELPNLARMID LLPSSSRNSS SSSSSRSRVA EDAEMPVPLT
KLLSKCQQGL AMGFAPQLAW DGTGGTYVLR DASRAPLAAF KPRDEEAFAP NNPRGLPGKL
GQPGIHGSIA SGEAHVREVL AHRLDHGHFA SVPLTLQAEA VHPAFYVHSH VALSRYGAKV
GSLQLWVPHD DVAANRGAAT FPTREVHKIA LLDMRLLNTD RNDSNILVRD MLARECELVP
IDHGGCLPSS AAISWFDWCW LSWPQMSVPP DAETRAYAKL LAEYGVPPAA IRASCCATLL
VQATVAAGLS LLDAALLLCR PDDDAPSELE RLIAQAERLT AHALSKPRLP EERRVRHASY
EQAYALSNPR LRSHADGAIY SPDLKQPKQR QAVGFGARPD RSLSAEDLSS LDARGSAPAS
PRGGALPAAS LPTLLHRVSS ERAIGSATAS SPSASCGATG GTGPAAAGAC GGASSLLDGH
IAFDGSAAEE TFYDENNLAR LVPRSSRSSI KEDEEDSS
//
