ID R1FRX5_EMIHU Unreviewed; 956 AA.
AC R1FRX5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Peptidase M16 {ECO:0000313|EMBL:EOD38401.1};
GN ORFNames=EMIHUDRAFT_471473 {ECO:0000313|EMBL:EOD38401.1};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD38401.1};
RN [1] {ECO:0000313|EMBL:EOD38401.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD38401.1};
RG DOE Joint Genome Institute;
RA Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT "Genome variability drives Emilianias global distribution.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [3] {ECO:0000313|EnsemblProtists:EOD38401}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; KB864032; EOD38401.1; -; Genomic_DNA.
DR RefSeq; XP_005790830.1; XM_005790773.1.
DR STRING; 2903.R1FRX5; -.
DR MEROPS; M16.A09; -.
DR PaxDb; 2903-EOD38401; -.
DR EnsemblProtists; EOD38401; EOD38401; EMIHUDRAFT_471473.
DR GeneID; 17283672; -.
DR KEGG; ehx:EMIHUDRAFT_471473; -.
DR eggNOG; KOG0959; Eukaryota.
DR HOGENOM; CLU_004639_1_1_1; -.
DR OMA; VGHQWLE; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000013827};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..956
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014593153"
FT DOMAIN 66..199
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 226..314
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 405..690
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
SQ SEQUENCE 956 AA; 103739 MW; 1EEA68A7ECF9FDFF CRC64;
MRAATESASR RALLSLCSAL LATPTPSPAA AAAAAAAARG LQTFDIAASD LDRRSFRGMQ
LSNGLRVLLC SDPEAGKAAA SMNVAVGSMS NPVEWPGLAH FCEHMLFLGT KRFPGEGEFE
RFIAANAGSN NAFTGSEETN YFFSVNGDAL PGALTRFADF FTAPLFSESG TTREVDAIDA
EHAKNLQSDF WRSDAVLRLR ARPDHPYSRF FTGNRQTLRG GDADARAALF AFHRAFYRAP
QMALAVAGPQ SLDALQRLVQ ANFGALPPGP APPASAAYDA LPPPFDTQPQ AEPPVATVLV
PVREQRSVTV TWCLPVEDPD EWWRAKPDST VLLKAKGLAS SVDGSIDEFT RSFVVLTAYI
GLTPQGLQRW PEVVSALFSY LALLREEGVP PHVYAEERRM RELAFAFAEP APPSSFVQSA
SGNLFLFPPR EWLRGPLLAG EGAEPLVRSI LEGLTPQAAV VKLTARELAP LATRVEPVYS
ASYGEMPIGR EVAAWSAAPR LDGLAVPPPN RFIPTDLSIK ALSIKARGAS TAQGGGGAAR
RVKPALLLNT DSDERFGRPK AFAFVSLRTP QLYESAAAAA QAELYAALLS DALQDVTYQA
ARAGLSAGAS VGWQGLSLSL SGYDQRLPEL AALVADSLRT FDVAPLAFER QRDGLLRQLR
GADKRQPVEQ AAYRRNLALE TPRYTNEQLA AGLEKATLPQ VLGLQRRLLP EVEVEALLCG
NVAEGQATQL VLKLLNALGS RPLPVARRPV RRVRVLPAGE RTLQQFVAAS QAEVNSATEV
YFQVGGDEAD DWVLLTLLSQ LMQQLGYIVQ CSANEIDGVR GLSFLVQSKV AAPEAVEERI
EAFLRLFRGT LLLLGEAEVQ SYAASIAAQF TDAGRLWAEC TRRRYDFERP WRSAEKVKRL
TREQLIAFFD RHVASGSPTR RQLSTHVYAQ SMAPPQLRVQ LPGDDFYPAP RDLLLV
//
