ID R1G9Y5_NANST Unreviewed; 744 AA.
AC R1G9Y5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=valine--tRNA ligase {ECO:0000256|ARBA:ARBA00013169};
DE EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
GN ORFNames=Nst1_391 {ECO:0000313|EMBL:EOD42659.1};
OS Nanobsidianus stetteri.
OC Archaea; Nanoarchaeota; Candidatus Nanoarchaeia; Nanoarchaeales;
OC Nanopusillaceae; Nanobsidianus.
OX NCBI_TaxID=1294122 {ECO:0000313|EMBL:EOD42659.1, ECO:0000313|Proteomes:UP000053279};
RN [1] {ECO:0000313|EMBL:EOD42659.1, ECO:0000313|Proteomes:UP000053279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Podar M., Makarova K.S., Graham D.E., Wolf Y.I., Koonin E.V.,
RA Reysenbach A.-L.;
RT "Insights into archaeal evolution and symbiosis from the genomes of a
RT Nanoarchaeon and its crenarchaeal host from Yellowstone National Park.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-
CC tRNA(Val); Xref=Rhea:RHEA:10704, Rhea:RHEA-COMP:9672, Rhea:RHEA-
CC COMP:9708, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57762,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78537, ChEBI:CHEBI:456215; EC=6.1.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001624};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOD42659.1}.
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DR EMBL; APJZ01000002; EOD42659.1; -; Genomic_DNA.
DR AlphaFoldDB; R1G9Y5; -.
DR PATRIC; fig|1294122.7.peg.377; -.
DR Proteomes; UP000053279; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004832; F:valine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07962; Anticodon_Ia_Val; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033705; Anticodon_Ia_Val.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR InterPro; IPR002303; Valyl-tRNA_ligase.
DR PANTHER; PTHR11946:SF93; VALINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2; 1.
DR PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000313|EMBL:EOD42659.1}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EOD42659.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000053279}.
FT DOMAIN 14..597
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 637..734
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 744 AA; 89082 MW; 669E5826D6370363 CRC64;
MDKRPDYKII EKEILNLWNK NKEIFKFDIN KDKRYIIDTP PPFTSGEAHM GHALEFIWID
FLARYKRLEG YNVYFPLGFD CHGLPTELKV INKLKISKEN KEQFIKACID WTNKMIESMY
KTFERLGSSF DRDKVYKTID RKYEAFVQYT LIKMFNDNLI ERKRYPIMWC PKCQTAISMQ
EAGYLEKEGY LIYIKLPTNN GKYILIATTR PELINSCSLI LIAKNKYVET ENNLIISKAY
AEKNNLKIIR EYDYKELENL EVTIPLINRK AKIISDNDVD YNFGTGIVWI CTYGDPYDIK
WKEKYNLPEI ISISEDGRII SNINEINGLK VEEAREKMKE ILKDYIYKIE KINHNVLSHT
ERSDCLSPLE FIPKEQFFIK IKDLKEKILE WQKDIKIIPE SEVKRLIDWI NNIDQDWNIS
RTKMLWGLTF PFYEKDGKIY PVNIEDLPID PRIEKEKVKK YNGKFFEDET VDVWIESSIT
PLVILYYALT ENKEFNPKEL PELFNKIKEY LPVDLRQQGY EIIRTWLFDT IVRVNLLTNK
NPWKYALIHG MVLDEKGRKM SKSLGNAINP NEIMDKYSPD ALRYWALLAA PGNDYRFNIK
DIESGQAFII KLWNIGRYIE MNIKEKPEKV LELKDEDREI IKILEENIKE SKEYVDQFRY
SEYVKLWRKF TWEDFANNYL EKIKERIKND DKTAKYLLYT IYKIILIMLH PILPYITEYI
YQQLYKENKL IIENKIDEIM KLIL
//
