ID R2Q161_9ENTE Unreviewed; 817 AA.
AC R2Q161;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Acetyl-CoA acetyltransferase {ECO:0000256|ARBA:ARBA00044137};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
DE AltName: Full=Acetoacetyl-CoA thiolase {ECO:0000256|ARBA:ARBA00030755};
GN ORFNames=UAS_00622 {ECO:0000313|EMBL:EOH89083.1};
OS Enterococcus asini ATCC 700915.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158606 {ECO:0000313|EMBL:EOH89083.1, ECO:0000313|Proteomes:UP000013777};
RN [1] {ECO:0000313|EMBL:EOH89083.1, ECO:0000313|Proteomes:UP000013777}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700915 {ECO:0000313|EMBL:EOH89083.1,
RC ECO:0000313|Proteomes:UP000013777};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus asini ATCC_700915.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOH89083.1}.
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DR EMBL; AJAP01000007; EOH89083.1; -; Genomic_DNA.
DR AlphaFoldDB; R2Q161; -.
DR STRING; 57732.RU94_GL001632; -.
DR PATRIC; fig|1158606.3.peg.581; -.
DR eggNOG; COG0183; Bacteria.
DR eggNOG; COG1257; Bacteria.
DR HOGENOM; CLU_017993_1_0_9; -.
DR Proteomes; UP000013777; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 1.10.8.660; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR NCBIfam; TIGR00532; HMG_CoA_R_NAD; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000013777};
KW Transferase {ECO:0000313|EMBL:EOH89083.1}.
FT DOMAIN 20..271
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 281..401
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
SQ SEQUENCE 817 AA; 86699 MW; EDFE28B267D4BE9E CRC64;
MFFISIMVYC KMEVANLKEV VIIDGLRTPI GKYKGMLKDL SAVELGSAVT KALLTKYPEA
KADVTQVIFG NVLQAGTGQN PARQIALKSG LDYAVTAATI NEVCGSGMKA VLMARQAIQL
GEAEVVLAGG IESMTRAPGV ATFDYDTKTY GAPLASMIID GLTDAQSGEH MGLTAENVAE
RYQVSRKEQD AFALASQQKA AQARSQGLFK NEILPLQVGE HLLTEDEGIR GNSTLEKLAT
LRPAFKEGGT VTAGNASTIN DGAAALLLAS KDYAEAHSIP YLAIVKETAE VGIDPAIMGI
SPITAIRQLV EKSGVSLDDI DLYEINEAFA ASSIVVEQEL GLPKEKVNIY GGGISLGHAI
GATGARLLTT LSHQLQDKDK RYGIASLCIG GGLGMAVLLE RPQPTKAKRF YELTAEERLQ
KLVADGAITP EVYATFKDTA LDSEISSHLI ENAISEVEIP LGVAQHLEVN GRKYLVPVAT
EEPSVIAALS NGAKIAGNFT SRILSRLMRG QIVFYDVPNQ EALIDWLKAQ EAHFFAVAKE
AHPSIYRRGG GLREIHTRKV GEDFVSCDFL VDVQEAMGAN IVNTILEAVA SEIRSLRVEP
ILFAILSNLT TESLVTTSCR IPVTRLGAKN GSEIAAKIAQ AATYAQLDPY RAATHNKGIM
NGIDGILLAT GNDTRAQAAA IHAYAASQGQ YQGLSQWQVV GDELVGELTL PLAVGTVGGG
TRVLPKAQAA MALLNVSGAA ELAQVIVSAG LAQNLAALKA LVGEGIQRGH MALQARSLAM
TVGAKGAEIP ELSRQLKKAP HMNEETAKEL LAKMRQS
//
