ID R2SAK6_9ENTE Unreviewed; 465 AA.
AC R2SAK6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN ORFNames=UAS_02071 {ECO:0000313|EMBL:EOH85169.1};
OS Enterococcus asini ATCC 700915.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158606 {ECO:0000313|EMBL:EOH85169.1, ECO:0000313|Proteomes:UP000013777};
RN [1] {ECO:0000313|EMBL:EOH85169.1, ECO:0000313|Proteomes:UP000013777}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700915 {ECO:0000313|EMBL:EOH85169.1,
RC ECO:0000313|Proteomes:UP000013777};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus asini ATCC_700915.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOH85169.1}.
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DR EMBL; AJAP01000022; EOH85169.1; -; Genomic_DNA.
DR RefSeq; WP_010754692.1; NZ_KB946294.1.
DR AlphaFoldDB; R2SAK6; -.
DR STRING; 57732.RU94_GL002088; -.
DR GeneID; 78364723; -.
DR PATRIC; fig|1158606.3.peg.2018; -.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_025068_2_2_9; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000013777; Unassembled WGS sequence.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000013777};
KW Transferase {ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 330
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 391
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 465 AA; 51928 MW; A824EB2E764C8830 CRC64;
MNVNEKNLLD YPSLALRCQG VDLIDVNNYS KYNVKRGLRD TNGKGVLAGL TTISTIYPQK
IVNGVPIPGT GELRYRGIDI EEIVQGFVGE GRFGFEEVAF LLLFGELPSP DELQEFRLLL
AEKQTLPTNF VRDVIMKAPS ADIMNNLSRS LLTLACYDDK RDDVSIENVL EQSLMLISVF
PMLAVYAYHA YNHYEKSESM YIHRPDPNLS TAETILTMLR PDKSYTKQEA QTLDMSLVLH
MEHGGGNNST FTTRVVTSSG TDTYSTISAA LGSLKGPKHG GANIKVTQMM EDLKATVADT
TDEAQVRQYL EAILDKKAFD GKGLIYGMGH AVYSDNDPRA AIFKAYVSKL AEEKGPEEQA
EFELYTLVER LAPEIIGEKR KMFKGVSANI DFFSGFVYAM LGLPRELYTP MFAVARIVGW
SAHRMEELIN AQKIIRPAYM EVSADRAYIP LANRTCTNEP VEELM
//
