ID   R2SW83_9ENTE            Unreviewed;       618 AA.
AC   R2SW83;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Tyrosine decarboxylase {ECO:0000313|EMBL:EOH99465.1};
GN   ORFNames=UAW_00617 {ECO:0000313|EMBL:EOH99465.1};
OS   Enterococcus haemoperoxidus ATCC BAA-382.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1158608 {ECO:0000313|EMBL:EOH99465.1, ECO:0000313|Proteomes:UP000013858};
RN   [1] {ECO:0000313|EMBL:EOH99465.1, ECO:0000313|Proteomes:UP000013858}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-382 {ECO:0000313|EMBL:EOH99465.1,
RC   ECO:0000313|Proteomes:UP000013858};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Enterococcus haemoperoxidus BAA-382.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOH99465.1}.
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DR   EMBL; AJAR01000010; EOH99465.1; -; Genomic_DNA.
DR   RefSeq; WP_010760827.1; NZ_KE136479.1.
DR   AlphaFoldDB; R2SW83; -.
DR   STRING; 155618.RV06_GL001038; -.
DR   PATRIC; fig|1158608.3.peg.595; -.
DR   eggNOG; COG0076; Bacteria.
DR   OrthoDB; 9803665at2; -.
DR   Proteomes; UP000013858; Unassembled WGS sequence.
DR   GO; GO:0004058; F:aromatic-L-amino-acid decarboxylase activity; IEA:UniProt.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR021115; Pyridoxal-P_BS.
DR   InterPro; IPR049373; TyrDC_C.
DR   InterPro; IPR022397; Tyrosine_deCO2ase_bac.
DR   NCBIfam; TIGR03811; tyr_de_CO2_Ent; 1.
DR   PANTHER; PTHR42735; -; 1.
DR   PANTHER; PTHR42735:SF4; TYROSINE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   Pfam; PF21391; tyr_de_CO2_C; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50}.
FT   DOMAIN          471..611
FT                   /note="L-tyrosine decarboxylase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21391"
FT   MOD_RES         390
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   618 AA;  69739 MW;  3BF5C2812D3496DE CRC64;
     MKNFNTDDTN LKALFLGDKG ENVDLFKELL NKMIDEHVGW RQNYMPQDLP VISPQDRSSK
     SFQETADNMR SVFNVLSSRL RTESLPWHSA GRFWGHMNAE TLMPSIIAYT TAMLWNGNNV
     AYESSPATSQ MEEEVGLEFA TLMGYEDGWG HIAADGSIAN LEGLWYARNM KSLPWAIQAV
     APEMVAGKSD WELLNMPTSE VLDILDQLQD KFDEIKANSA RSGKNLDKLG KWIVPQTKHY
     SWLKAADIIG IGLDQVIAGE VNSEYRMDID KLEAQIRDLA AQGIPTLGVV GVVGSTEEGQ
     VDRIDQIIAL RDKLAKEGIY FYVHVDAAYG GYGRSIFLDE NDQFIEWDKI EEVYAKHNIF
     QEKNDWLTRE VYESFKAIEQ AESVTIDPHK MGYIPYSAGG VVIKDIRMRD VISYFATYVF
     EKGADIPALL GAYILEGSKA GATAAAVWTA HKVLPLNVTG YGKLMGASIE GAYHFYHFID
     GLEFKVGNKI IEIHALTKPD FNMVDYVFNE KGNTDLVKMN KLNHDFYDYA SYTKGGLYNN
     EFITSHTDFA IEEYGHSPFE FVNSLGFSRA EWERADKVTI LRAAGMSPYM NDKEVFDDYA
     EKIKVAIQEK LEAIYAEQ
//