ID R2VHI9_9ENTE Unreviewed; 1072 AA.
AC R2VHI9;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=UKC_01275 {ECO:0000313|EMBL:EOI57061.1};
OS Enterococcus gilvus ATCC BAA-350.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158614 {ECO:0000313|EMBL:EOI57061.1, ECO:0000313|Proteomes:UP000013750};
RN [1] {ECO:0000313|EMBL:EOI57061.1, ECO:0000313|Proteomes:UP000013750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-350 {ECO:0000313|EMBL:EOI57061.1,
RC ECO:0000313|Proteomes:UP000013750};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus gilvus ATCC BAA-350.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the serine-aspartate repeat-containing protein
CC (SDr) family. {ECO:0000256|ARBA:ARBA00007257}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOI57061.1}.
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DR EMBL; AJDQ01000006; EOI57061.1; -; Genomic_DNA.
DR RefSeq; WP_010779694.1; NZ_KB946874.1.
DR AlphaFoldDB; R2VHI9; -.
DR PATRIC; fig|1158614.3.peg.1284; -.
DR eggNOG; COG2304; Bacteria.
DR eggNOG; COG4932; Bacteria.
DR HOGENOM; CLU_010203_0_0_9; -.
DR OrthoDB; 2194739at2; -.
DR Proteomes; UP000013750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 2.60.40.2110; -; 1.
DR Gene3D; 2.60.40.1140; Collagen-binding surface protein Cna, B-type domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR049319; GBS104-like_Ig.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR041033; Prealbumin-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR36108:SF13; COLOSSIN-B; 1.
DR PANTHER; PTHR36108; COLOSSIN-B-RELATED; 1.
DR Pfam; PF21426; GBS104-like_Ig; 1.
DR Pfam; PF17802; SpaA; 2.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Secreted {ECO:0000256|ARBA:ARBA00022512}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1072
FT /note="VWFA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004366519"
FT TRANSMEM 1045..1067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 314..588
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1035..1072
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 164..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1072 AA; 119355 MW; 54FC522830458CAC CRC64;
MKKTNIVIFL MLLFSIIAEA AVTVVSVHAE AKDIQLVDEK WLDLSYTYEK EGESNQWVVS
YEHQSEEKDA PRRMKFRVTD EKDQVIEYPK HETMTEKEGW LIEENFSEKS DGRLVLEVPR
AINALHLYVQ MDQQSEPAKD GDAPKIHENI VERQAPFALE RTNKATKKVT KASTETEQST
DERIGPKKEN TPMAATASAA QPYGTSRMYN QLYTNKETKY KHDAGTYPEF SWQPTGQTNV
INHQGGVAGQ TGWDGVKNWN VANDTYSNSY IKYGGEATKP NFLLRKYAQE TSEPDEFKIK
LNVRGNTTYK PGVDIVFLLD NTGSMAGAKK KQSADAMQKI VDKLQEISGG DANSIRVGGH
IFASYNKSIE GQWGWTRTKT HHKLSNKPSD WQNMVKVYRN LTPAGMTFTQ RGLQEAEDIF
NASGSSLGED RYKLLFVLTD GAPNISWKPT SAVREPSMFY DQTLITGFDS GYAPNYNGEH
TFEGTGINTK FAKNFLVNGQ PITSHLTTTN STAYKLKNSG IEIHSLAVQI RSTGDGDHPA
ATLLEGMYKM ATKKANAKTD TQNDYFFYHA KNDTGSLTEY VKSWYDTIIR TVDKGIVLDP
LGDMVELVTT NGKAPKVKQV SNSAPVIAQE DMARVKSTNN NRQIELENIN LTQNQEIELE
YTVKLKTNDS NFVSNHWYPA NNKTMLYPTP ERTNDEMEFG RPSVRLQKDE FVIPVEKIWS
DKLATETDNY WGMRGSKVTA KLQRLAGSTW TDVQSLTLNA ANQWKGTFSP VDGSSGNTYR
VVEPTRTNGY KKASLNQGIF TSDTMPNGGI KITNELLRGD YSFWKVMGDG KTPFTTDLPK
FKVTRSDGKV LAENLAPEAG TGKVTIKNMP IGTYTVEETY VPKGFQKMAK FTIEATENNS
SAPSSVVFKV NGSTGKHAVR NQLTDFSLIV EKVDDHDAWI SGATFKLTGP NYNETIAGGP
IFDFMLLQPG KYTLTETDSP NGYGMLTTPI TFEIKEDGKC VIDDHGNVTE SSITINDENA
IYLKVLNKKV RTGVLPQTGA FGVQGLTLIA GTLVLGGVML GILSLYLNRS KK
//
