ID R3TSX6_9ENTE Unreviewed; 1011 AA.
AC R3TSX6;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00013303, ECO:0000256|RuleBase:RU361154};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|RuleBase:RU361154};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230, ECO:0000256|RuleBase:RU361154};
GN ORFNames=UC3_01501 {ECO:0000313|EMBL:EOL44684.1};
OS Enterococcus phoeniculicola ATCC BAA-412.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158610 {ECO:0000313|EMBL:EOL44684.1, ECO:0000313|Proteomes:UP000013785};
RN [1] {ECO:0000313|EMBL:EOL44684.1, ECO:0000313|Proteomes:UP000013785}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-412 {ECO:0000313|EMBL:EOL44684.1,
RC ECO:0000313|Proteomes:UP000013785};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus phoeniculicola BAA-412.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412,
CC ECO:0000256|RuleBase:RU361154};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOL44684.1}.
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DR EMBL; AJAT01000013; EOL44684.1; -; Genomic_DNA.
DR RefSeq; WP_010768164.1; NZ_KB946327.1.
DR AlphaFoldDB; R3TSX6; -.
DR STRING; 154621.RV11_GL002433; -.
DR PATRIC; fig|1158610.3.peg.1486; -.
DR eggNOG; COG3250; Bacteria.
DR HOGENOM; CLU_002346_0_2_9; -.
DR OrthoDB; 9762066at2; -.
DR Proteomes; UP000013785; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW Reference proteome {ECO:0000313|Proteomes:UP000013785}.
FT DOMAIN 730..1008
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1011 AA; 117101 MW; 75749D689EFFD529 CRC64;
MFKNHQILHE NREKPHSHFH SYESKEEAVS FERKKSMGFQ LLNGEWSFSL TELLERVPEG
FFGEETLSDK WSEIQVPGHW QLQGYGNPHY TNVAYPFPVE PPYIPTKNPT GYYKREVFFS
KTSSERKTII CFEGVDNAFK LWVNDQYIGY STGSRTPAEF DLTNVLVEGK NSIQVQVCQW
SAMSYLEDQD MWWLSGIFRD VYLYERQKEG IYDLFIRPEL DDSYTVGHLA IDYCFKERKD
EKEYTIKVEV TDPTNSSVML DETMSATGKE VSHHFKIDNP KHWTAETPHL YQLIIEVYKE
KRLIQVIPQK IGFRTVEVKD GLIQVNGQPI LFKGVNRHDW HPTLGRAVPL SYLEKDIQLM
KEFNINAVRT AHYPNDPRFY DLCDFYGLYV IDEADIETHG MDIVNRRNEL SDHIDWQPAY
LDRVKRMVIR DQNHPSILIW SLGNESGFGQ NHQAATDWIR SYDQTRLIHY EGESRHIFEN
ELEQKNHATD LFSTMYTSVE KMQIEGKKRA LEQPHILCEY AHAMGNGPGG LKEYMDLFYK
YPRLQGGFVW EWIDHGIQQT TPSGEVYYAY GGDFGDKPND SNFIIDGLIF PDRTPSPALY
EYKKVIEPVT IEFSADNRQV HLINRFDFRN LNTLSAQFVW KMNGQILDVV AVENIDIEPR
EAATILVPKP TADVTHYEGE VVLSLIFKEP KGRFIYSDKV AWKQAIVKSA LPKLIEKKAF
SSMVEDEKLT ISSNDVQLCF DLKTGHMLEW TYRGKPLVTG QPKINFWRAV TDNDRLGQDE
FYTAPMTDEW YEYGIHQLAE RVESVQVDEQ EEAMLIVINS TQAAVSRDWG IRLEKTYRIF
GKGAVEISVK GIPFGNKPKT LPKIGLQLYL AKELQTVNWY GFGPNETYAD SCQSGYLDSW
EKSVNEMFTP YVRPQENGNR METRNVTIRN EAGVGVTISG TPFQFSVRNY STEQLDEAEH
TYELTELDAV ELNLDYRQYG LGSASCGPEV AEAYKLYNEP FNFSFVLDYA D
//
