ID R4FLH4_RHOPR Unreviewed; 499 AA.
AC R4FLH4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Putative xaa-pro aminopeptidase {ECO:0000313|EMBL:JAA75401.1, ECO:0000313|EnsemblMetazoa:RPRC014463-PA};
OS Rhodnius prolixus (Triatomid bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX NCBI_TaxID=13249 {ECO:0000313|EMBL:JAA75401.1};
RN [1] {ECO:0000313|EMBL:JAA75401.1}
RP NUCLEOTIDE SEQUENCE.
RA Ribeiro J.M.C., Genta F.A., Sorgine M.H.F., Paiva-Silva G.O.,
RA Majerowicz D., Medeiros M., Koerich L., Terra W.R., Ferreira C.,
RA Pimentel A.C., Bisch P.M., Diniz M.M.P., Nascimento R., Salmon D.,
RA Silber A.M., Alves M., Oliveira M.F., Gondim K.C., Silva Neto M.A.C.,
RA Atella G.C., Araujo H., Dias F.S., Polycarpo C.R., Fampa P., Melo A.C.,
RA Tanaka A.S., Balczun C., Oliveira J.H.M., Goncalves R., Lazoski C.,
RA Pereira M.A., Rivera-Pomar R., Diambra L., Schaub G.A., Garcia E.S.,
RA Azambuja P., Braz G.R.C., Oliveira P.L.;
RT "An insight into the transcriptome of the digestive tract of the blood
RT sucking bug, Rhodnius prolixus.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000015103}
RP NUCLEOTIDE SEQUENCE.
RA Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:RPRC014463-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
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DR EMBL; ACPB03003540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ACPB03003541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GAHY01002109; JAA75401.1; -; mRNA.
DR AlphaFoldDB; R4FLH4; -.
DR STRING; 13249.R4FLH4; -.
DR EnsemblMetazoa; RPRC014463-RA; RPRC014463-PA; RPRC014463.
DR VEuPathDB; VectorBase:RPRC014463; -.
DR eggNOG; KOG2414; Eukaryota.
DR HOGENOM; CLU_017266_1_1_1; -.
DR InParanoid; R4FLH4; -.
DR OMA; DSYFWYL; -.
DR OrthoDB; 1377484at2759; -.
DR Proteomes; UP000015103; Unassembled WGS sequence.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01087; Prolidase; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR007865; Aminopep_P_N.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR001714; Pept_M24_MAP.
DR PANTHER; PTHR43226; XAA-PRO AMINOPEPTIDASE 3; 1.
DR PANTHER; PTHR43226:SF4; XAA-PRO AMINOPEPTIDASE 3; 1.
DR Pfam; PF05195; AMP_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR PRINTS; PR00599; MAPEPTIDASE.
DR SMART; SM01011; AMP_N; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 2: Evidence at transcript level;
KW Aminopeptidase {ECO:0000313|EMBL:JAA75401.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000313|EMBL:JAA75401.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015103}.
FT DOMAIN 70..209
FT /note="Aminopeptidase P N-terminal"
FT /evidence="ECO:0000259|SMART:SM01011"
SQ SEQUENCE 499 AA; 56587 MW; 18450F7B1D8D65DF CRC64;
MKFFRLNRGL NWQLYPCFLN IRESTILRRK LSDHGIKVRT PLSGITRTLG QPSPDSHPHL
LKANELVPGF TVKDFIERRE KLVMEILKFK SGIFQVILVP SSPIHYMTEK IPYVFRQNTD
FRYLTGCLEP DSALLIVIES ENKFRSTLFL REKNNHSELW EGPRTGVEIA PDVFGVDDAK
PFQELENVLR DIGNKNVTLW YDALNPVNAV VHRCVASFLS DKGEKELFEV RQKIHELRVV
KSLAEQELMI KSAEIASDAI KLTLMSTKPG VTEHQLFATV DYHCRMKGAE FLAYPPVVAA
GDNANIIHYI NNSQQIKKED LILMDAGCEL HGYCSDITRT WPASGSFSPF QRTLYDVVLS
VQLDLISSCR DISSLDHLFT IMCKLLGRRL KEAHVLSKAA SNLTLEQIAF KLCPHHVGHY
LGMDVHDTAT VPRKAQLKEG MIITVEPGLY INSTNILTKP EFRGIGIRIE DDVLFTNKGP
KVISTCPKSV DEIENLCKR
//
