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Database: UniProt
Entry: R4GBC9_ANOCA
LinkDB: R4GBC9_ANOCA
Original site: R4GBC9_ANOCA 
ID   R4GBC9_ANOCA            Unreviewed;       300 AA.
AC   R4GBC9;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   11-DEC-2019, entry version 43.
DE   SubName: Full=ETS homologous factor {ECO:0000313|Ensembl:ENSACAP00000022602};
GN   Name=EHF {ECO:0000313|Ensembl:ENSACAP00000022602};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000022602, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000022602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000022602};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L., Mauceli E.,
RA   Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A., Boissinot S.,
RA   Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K., Fujita M.K.,
RA   Moreno R.G., Ten Hallers B.F., Haussler D., Heger A., Heiman D.,
RA   Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y., Lara M., Novick P.A.,
RA   Organ C.L., Peach S.E., Poe S., Pollock D.D., de Queiroz K., Sanger T.,
RA   Searle S., Smith J.D., Smith Z., Swofford R., Turner-Maier J., Wade J.,
RA   Young S., Zadissa A., Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B.,
RA   Lander E.S., Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with birds
RT   and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000022602}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AAWZ02023349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003225216.1; XM_003225168.3.
DR   STRING; 28377.ENSACAP00000022602; -.
DR   Ensembl; ENSACAT00000030019; ENSACAP00000022602; ENSACAG00000028492.
DR   GeneID; 100566762; -.
DR   KEGG; acs:100566762; -.
DR   CTD; 26298; -.
DR   eggNOG; KOG3804; Eukaryota.
DR   eggNOG; ENOG4111K4J; LUCA.
DR   GeneTree; ENSGT00940000159310; -.
DR   KO; K17102; -.
DR   OrthoDB; 837296at2759; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000028492; Expressed in 1 organ(s), highest expression level in kidney.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0050673; P:epithelial cell proliferation; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR033071; EHF.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF171; PTHR11849:SF171; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT   DOMAIN          29..115
FT                   /note="PNT"
FT                   /evidence="ECO:0000259|PROSITE:PS51433"
FT   DOMAIN          207..289
FT                   /note="ETS"
FT                   /evidence="ECO:0000259|PROSITE:PS50061"
SQ   SEQUENCE   300 AA;  34944 MW;  44A9BEEBA02D7456 CRC64;
     MILEGTGRMS LNSVTSLLHE QPSWTDGYPP CNATGSFFGT QWHEIHPQYW TKYQVWEWLQ
     HLLDTNQLDA NCIPFQEFDI SGEHLCNMNL QDFTRAAGTA GQLLYSSLHH LKWNGQFGSE
     MYPSQNIIVK TEQADPCAMT SWKDDNYFYD NGYGGTVELV DSKAYCRAQI SINAANHQPI
     EDSSDVKKIA QEHTPKSHNK KHTPRGTHLW EFIRDILLHP EKNPGLIKWE DRSEGIFRFL
     KSEAVAQLWG KKKNNSSMTY EKLSRAMRYY YKREILERVD GRRLVYKFGK NARGWRENEN
//
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