ID R4GBV9_ANOCA Unreviewed; 322 AA.
AC R4GBV9;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Mitochondrial glutamate carrier 1 {ECO:0000256|ARBA:ARBA00040262};
DE AltName: Full=Glutamate/H(+) symporter 1 {ECO:0000256|ARBA:ARBA00041922};
DE AltName: Full=Solute carrier family 25 member 22 {ECO:0000256|ARBA:ARBA00041877};
GN Name=SLC25A22 {ECO:0000313|Ensembl:ENSACAP00000022803.1};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000022803.1, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000022803.1, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000022803.1,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000022803.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-glutamate(in) = H(+)(out) + L-glutamate(out);
CC Xref=Rhea:RHEA:70955, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985;
CC Evidence={ECO:0000256|ARBA:ARBA00036753};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR RefSeq; XP_008106521.1; XM_008108314.2.
DR RefSeq; XP_008106526.1; XM_008108319.2.
DR AlphaFoldDB; R4GBV9; -.
DR Ensembl; ENSACAT00000030221.2; ENSACAP00000022803.1; ENSACAG00000028980.2.
DR GeneID; 100564494; -.
DR KEGG; acs:100564494; -.
DR CTD; 79751; -.
DR eggNOG; KOG0750; Eukaryota.
DR GeneTree; ENSGT00940000161196; -.
DR HOGENOM; CLU_015166_3_4_1; -.
DR InParanoid; R4GBV9; -.
DR OrthoDB; 1220009at2759; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000028980; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005280; F:amino acid:proton symporter activity; IEA:Ensembl.
DR GO; GO:0015183; F:L-aspartate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005313; F:L-glutamate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015810; P:aspartate transmembrane transport; IBA:GO_Central.
DR GO; GO:0015813; P:L-glutamate transmembrane transport; IBA:GO_Central.
DR GO; GO:0043490; P:malate-aspartate shuttle; IBA:GO_Central.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45678; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED; 1.
DR PANTHER; PTHR45678:SF3; MITOCHONDRIAL GLUTAMATE CARRIER 1; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 6..93
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 101..213
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 222..311
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 322 AA; 34830 MW; 18F2A024BA7137BB CRC64;
MADKQISLPA KLINGGIAGL IGVTCVFPID LAKTRLQNQQ NGQRMYSSMS DCLIKTIRSE
GYFGMYRGAA VNLTLVTPEK AIKLAANDFF RHHLARDGKK LTLLKEMLAG CGAGTCQVIV
TTPMEMLKIQ LQDAGRIAAQ KKLMAAQAQL NPSSGAAAAE SVMESRTTAM QITRDLLRSK
GIAGLYKGLG ATLLRDVPFS IVYFPLFANL NKLGQKSPDV KAPFYVSFLA GCVAGSTAAV
AVNPCDVIKT RLQSLQRGVN EDTYSGIVDC ARKIWQKEGP AAFLKGAYCR ALVIAPLFGI
AQVVYFIGIA EYILDMLPRR RD
//
