ID R4GC04_ANOCA Unreviewed; 215 AA.
AC R4GC04;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Fibroblast growth factor {ECO:0000256|RuleBase:RU049442};
DE Short=FGF {ECO:0000256|RuleBase:RU049442};
GN Name=fgf21 {ECO:0000313|Ensembl:ENSACAP00000022854.1};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000022854.1, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000022854.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000022854.1};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000022854.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000256|ARBA:ARBA00007936, ECO:0000256|RuleBase:RU049442}.
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DR RefSeq; XP_016852196.1; XM_016996707.1.
DR AlphaFoldDB; R4GC04; -.
DR STRING; 28377.ENSACAP00000022854; -.
DR Ensembl; ENSACAT00000030272.1; ENSACAP00000022854.1; ENSACAG00000017175.4.
DR GeneID; 100564275; -.
DR KEGG; acs:100564275; -.
DR CTD; 26291; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000161866; -.
DR InParanoid; R4GC04; -.
DR OrthoDB; 4138817at2759; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000017175; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR PANTHER; PTHR11486:SF81; FIBROBLAST GROWTH FACTOR 21; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00262; IL1HBGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
SQ SEQUENCE 215 AA; 24156 MW; 1288CC7E46573809 CRC64;
MVVVSVPLGC KDYLLFLVSL VFWAALLRTA PALPLRNSNP IYQFDGQVRL RHLYTADEQT
HLHLEILPDG TVGGSRFQNP FSLMEIKAVK PGVIRMQAKK TSRFLCMKPN GRLYGSLFYS
EEACNFHEKV LSDGYNLYYS ENYNIPVSLS SAGNLGQSRQ LPPFSQFLPL VNKIPLEPVL
EDFDFYGHQL DVESADPLSI LGQNPGFMSP SYVFG
//
