ID R4GC66_ANOCA Unreviewed; 406 AA.
AC R4GC66;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Serpin domain-containing protein {ECO:0000259|SMART:SM00093};
GN Name=LOC100567410 {ECO:0000313|Ensembl:ENSACAP00000022922.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000022922.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000022922.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000022922.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000022922.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC {ECO:0000256|ARBA:ARBA00006426}.
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DR RefSeq; XP_008116177.1; XM_008117970.2.
DR AlphaFoldDB; R4GC66; -.
DR STRING; 28377.ENSACAP00000022922; -.
DR MEROPS; I04.006; -.
DR Ensembl; ENSACAT00000030341.2; ENSACAP00000022922.2; ENSACAG00000029159.2.
DR GeneID; 100567410; -.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000154573; -.
DR HOGENOM; CLU_023330_0_2_1; -.
DR OrthoDB; 3218836at2759; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000029159; Expressed in dewlap and 11 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IBA:GO_Central.
DR CDD; cd19560; serpinB1_LEI; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR Gene3D; 2.10.310.10; Serpins superfamily; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF180; LEUKOCYTE ELASTASE INHIBITOR; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 40..406
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 406 AA; 46078 MW; 949263B472155B0A CRC64;
MDHLRGRAPR LASPPGMLLL RRERSFIMDQ LANANTHFAL DLFQKLTEAN STGNIFFSPL
NISSALAMVY LGAKGDTATL LSKACHFDAV EDLHVKLQAL STKINRSDAP YVLKLANRLY
GEKTYCFLKD YLTSTQKLYG AELSMVDFLN AAQSVRTQIN QWVEGQTEGK ITELLSEDSV
NELTKLVLVN AIYFKGSWEE KFDKFDTTDK PFRLSKKEKK NVKMMFMKKK LPFGYIDDCK
CRVLELPYQG KELSMILLLP DDIEDDSTGL EQLEKQLILG NLQKWTCSQN MYSNHEVYVH
LPKFKLEESY DLQSYLEALG LRDVFDSGKA DLSGMSRARD LHVSKIVHKS FVEVNEEGTE
AAAAAAAVAT NSMPMREKFN ADHPFLFFIR HNPTNTILFF GRFASP
//
