ID R4GMS4_HUMAN Unreviewed; 300 AA.
AC R4GMS4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Rho GTPase activating protein 19 {ECO:0000313|Ensembl:ENSP00000473327.1};
DE Flags: Fragment;
GN Name=ARHGAP19 {ECO:0000313|Ensembl:ENSP00000473327.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000473327.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000473327.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000473327.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL359385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; R4GMS4; -.
DR MaxQB; R4GMS4; -.
DR PeptideAtlas; R4GMS4; -.
DR Ensembl; ENST00000492211.5; ENSP00000473327.1; ENSG00000213390.11.
DR UCSC; uc057vds.1; human.
DR HGNC; HGNC:23724; ARHGAP19.
DR VEuPathDB; HostDB:ENSG00000213390; -.
DR GeneTree; ENSGT00940000157331; -.
DR Proteomes; UP000005640; Chromosome 10.
DR Bgee; ENSG00000213390; Expressed in trigeminal ganglion and 170 other cell types or tissues.
DR ExpressionAtlas; R4GMS4; baseline and differential.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF7; RHO GTPASE-ACTIVATING PROTEIN 19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:R4GMS4,
KW ECO:0007829|MaxQB:R4GMS4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 101..300
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000473327.1"
SQ SEQUENCE 300 AA; 33617 MW; 5F5F0290F82FF21B CRC64;
XTEAQSEGEV PARESGRSDA ICSFVICNDS SLRGQPIIFN PDFFVEKLRH EKPEIFTELV
VSNITRLIDL PGTELAQLMG EVDLKLPGGA GPASGFFRSL MSLKRKEKGV IFGSPLTEEG
IAQIYQLIEY LHKNLRVEGL FRVPGNSVRQ QILRDALNNG TDIDLESGEF HSNDVATLLK
MFLGELPEPL LTHKHFNAHL KIADLMQFDD KGNKTNIPDK DRQIEALQLL FLILPPPNRN
LLKLLLDLLY QTAKKQDKNK MSAYNLALMF APHVLWPKNG LVLLPTLEES NTITTHCSLI
//
