ID R4GN76_HUMAN Unreviewed; 71 AA.
AC R4GN76;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Clusterin like 1 {ECO:0000313|Ensembl:ENSP00000473520.2};
DE Flags: Fragment;
GN Name=CLUL1 {ECO:0000313|Ensembl:ENSP00000473520.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000473520.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000473520.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000473520.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the clusterin family.
CC {ECO:0000256|ARBA:ARBA00010069}.
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DR EMBL; AP001178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; R4GN76; -.
DR SMR; R4GN76; -.
DR MassIVE; R4GN76; -.
DR PeptideAtlas; R4GN76; -.
DR Antibodypedia; 21905; 103 antibodies from 21 providers.
DR Ensembl; ENST00000579912.5; ENSP00000473520.2; ENSG00000079101.18.
DR UCSC; uc060mst.1; human.
DR HGNC; HGNC:2096; CLUL1.
DR VEuPathDB; HostDB:ENSG00000079101; -.
DR GeneTree; ENSGT00530000063668; -.
DR HOGENOM; CLU_2564337_0_0_1; -.
DR ChiTaRS; CLUL1; human.
DR Proteomes; UP000005640; Chromosome 18.
DR Bgee; ENSG00000079101; Expressed in pigmented layer of retina and 124 other cell types or tissues.
DR ExpressionAtlas; R4GN76; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR000753; Clusterin-like.
DR PANTHER; PTHR10970; CLUSTERIN; 1.
DR PANTHER; PTHR10970:SF2; CLUSTERIN-LIKE PROTEIN 1; 1.
DR Pfam; PF01093; Clusterin; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Proteomics identification {ECO:0007829|PeptideAtlas:R4GN76,
KW ECO:0007829|ProteomicsDB:R4GN76};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..71
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036476892"
FT NON_TER 71
FT /evidence="ECO:0000313|Ensembl:ENSP00000473520.2"
SQ SEQUENCE 71 AA; 8189 MW; BC16E04F12AAEF0E CRC64;
MKPPLLVFIV CLLWLKDSHC APTWKDKTAI SENLKSFSEV GEIDADEEVK KALTGIKQMK
IMMERKEKEH T
//
