ID R4K2L7_CLOPA Unreviewed; 767 AA.
AC R4K2L7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=Clopa_0955 {ECO:0000313|EMBL:AGK95971.1};
OS Clostridium pasteurianum BC1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=86416 {ECO:0000313|EMBL:AGK95971.1, ECO:0000313|Proteomes:UP000013523};
RN [1] {ECO:0000313|EMBL:AGK95971.1, ECO:0000313|Proteomes:UP000013523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC1 {ECO:0000313|EMBL:AGK95971.1,
RC ECO:0000313|Proteomes:UP000013523};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Dunn J.,
RA Taghavi S., Francis A., van der Lelie D., Woyke T.;
RT "Complete sequence of chromosome of Clostridium pasteurianum BC1.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP003261; AGK95971.1; -; Genomic_DNA.
DR RefSeq; WP_015614295.1; NC_021182.1.
DR AlphaFoldDB; R4K2L7; -.
DR STRING; 86416.Clopa_0955; -.
DR KEGG; cpas:Clopa_0955; -.
DR PATRIC; fig|86416.3.peg.945; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_89_20_9; -.
DR OrthoDB; 9813394at2; -.
DR Proteomes; UP000013523; Chromosome.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 2.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:AGK95971.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000013523};
KW Transferase {ECO:0000313|EMBL:AGK95971.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 519..742
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 767 AA; 89643 MW; CD28B86D03A63C56 CRC64;
MKYTLKAIKK LFFCSNNNFI TKVSRDFVDF SGYSEYELVG KSLNEISMLL RINSVVNFED
IKDKFEGYMF TKQCNAREVT ILCKNLEGNN EREYYFREKP NSRIEDKMMF VAQICKNDKI
GTSIWSFPDF IMLNCNNKFL KYFYPSYAKR ENCIGKYKKE IVNGIEDDNI DKIWSTIKKT
GESYHINEFK HEDKVNGTSY WNLIFVPIYV DGNIKYIVEN KWDITEKIRG RELRDKQSKI
IENQKKQLEA IIENMAEPLL IVNKDGKYID INKAARNKYP MYRNLREAGK TYDKIEYFDI
DGKVIPKENL PVNRLLRGEK ISEFKSIVKY NNDFRYYNVN AAPVYDNEGD FIAGVMCIND
ITEKVKNDNH MFIDKQYKIL NRMIEELDLP VLRLSYPDLK LIDINKKAYN FLKLENSDIG
SISSIKGMNY KDVVNSFDKN YILKHVKGII EENKKSYSKY RKFTVFGKEK FINTIYQPIL
GINNEVLEIL AIGIDVTEEI MANKEMEKTL KVQEEIFANL SHEMRTPLNV IFSAVQLFEL
YSNNKSLCGD KEKLNRDIHS IKKNCYRLSR IINNMVDLSR IKLGYFEVNL SNQNIVSMLK
TIVKDISEYF EDKEINIVFN TNIDEKIIAY DANNICRVIL NLISNAIKFS ENSCEISIEL
IDKNNFIEIS VKDKGIGIEK NHLQHIFEKF KQVDKSFQRA TEGIGIGLYI VKSIVELHYG
NISVKSKLGE GSIFKVTLPA RTVETNNKKN IFFSDEMIKA EFSDIYL
//
