ID R4K762_CLOPA Unreviewed; 874 AA.
AC R4K762;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=Clopa_2663 {ECO:0000313|EMBL:AGK97516.1};
OS Clostridium pasteurianum BC1.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=86416 {ECO:0000313|EMBL:AGK97516.1, ECO:0000313|Proteomes:UP000013523};
RN [1] {ECO:0000313|EMBL:AGK97516.1, ECO:0000313|Proteomes:UP000013523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC1 {ECO:0000313|EMBL:AGK97516.1,
RC ECO:0000313|Proteomes:UP000013523};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Dunn J.,
RA Taghavi S., Francis A., van der Lelie D., Woyke T.;
RT "Complete sequence of chromosome of Clostridium pasteurianum BC1.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP003261; AGK97516.1; -; Genomic_DNA.
DR RefSeq; WP_015615815.1; NC_021182.1.
DR AlphaFoldDB; R4K762; -.
DR STRING; 86416.Clopa_2663; -.
DR KEGG; cpas:Clopa_2663; -.
DR PATRIC; fig|86416.3.peg.2656; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_9; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000013523; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000013523}.
FT DOMAIN 688..704
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 614..621
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 874 AA; 99103 MW; 5FFA1BCBBFC69319 CRC64;
MGLTPMMQQY MSVKEKCKDC ILFFRLGDFY EMFFEDAKTA SRELELVLTG KDCGLSERAP
MCGVPFHSAN MYITKLISKG YKVAIGEQLE DPAAAKGIVK RGIVKIVTPG TYTDSSFLED
TKNNYIMSIF VDEDKFGISI ADVSTGEFNC TSWNLERELI INEISKYSPK EILIQESLDE
KLLEAIKERF NCSFTKFQDE FFNKGAYENL KQQFLNFQEK KYDDLIVGSA NGLLRYLMDT
QKISLGHIDN ITHYNVIDYM SIDVNSRKNL ELTETLREKS KKGSLLWVLD KTSTAMGGRQ
LRRWIEEPLI DAKVINERLD SVQEFTENLS IHEDLKNALK QVYDIERLVG KISTLSVNAK
ELIFLKNSIE KLPGIKEILK DSKSTLLREI YEKLDDLKDI YDILDSAVLD SPSVSVKEGN
IIKDGYNNNV DELRQAKAHG KEWIAKLESS EREETGIKSL KVSYNKVFGY YIEITKSNLN
LVPEGRYIRK QTLANCERYI TEELKIMEEK ILGAEEKLIN VEYELFVSIR DEISKHIDRM
KQSAKLLSEL DCLCSFATVA LENNYCKPKI VEDGAIEIKE GRHPVVENML SAGAFVSNDT
KINTTDEQLM LITGPNMAGK STYMRQVALI VVMAQIGSFV PAREAIISVC DKIFTRIGAS
DDLAAGKSTF MVEMWEVSNI LKNATTKSLI ILDEVGRGTS TYDGLSIAWS VVEYLCINKD
VKCKTLFATH YHELTSLEGV IHGLKNYSIA VKQIQDDIVF LRKIVTGGAD QSYGIEVAKL
AGLPEKVTSR AKEILEELER ENKNEIAVDS ISKVSKEKNI KQKKKKDSEI VQLGFEDIKK
DEFLKNIAKV DIMNMTPMDC MNALYKIIKD AKNL
//
