ID R4KRC6_9FIRM Unreviewed; 355 AA.
AC R4KRC6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Multidrug resistance efflux pump {ECO:0000313|EMBL:AGL02166.1};
GN ORFNames=Desgi_2762 {ECO:0000313|EMBL:AGL02166.1};
OS Desulfoscipio gibsoniae DSM 7213.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC Desulfoscipio.
OX NCBI_TaxID=767817 {ECO:0000313|EMBL:AGL02166.1, ECO:0000313|Proteomes:UP000013520};
RN [1] {ECO:0000313|EMBL:AGL02166.1, ECO:0000313|Proteomes:UP000013520}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7213 {ECO:0000313|EMBL:AGL02166.1,
RC ECO:0000313|Proteomes:UP000013520};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Parshina S.,
RA Plugge C., Muyzer G., Kuever J., Ivanova A., Nazina T., Klenk H.-P.,
RA Brambilla E., Spring S., Stams A.F., Woyke T.;
RT "Complete sequence of Desulfotomaculum gibsoniae DSM 7213.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
CC -!- SIMILARITY: Belongs to the UPF0194 family.
CC {ECO:0000256|ARBA:ARBA00010602}.
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DR EMBL; CP003273; AGL02166.1; -; Genomic_DNA.
DR RefSeq; WP_006521897.1; NC_021184.1.
DR AlphaFoldDB; R4KRC6; -.
DR STRING; 767817.Desgi_2762; -.
DR KEGG; dgi:Desgi_2762; -.
DR eggNOG; COG1566; Bacteria.
DR HOGENOM; CLU_018816_6_1_9; -.
DR OrthoDB; 250565at2; -.
DR Proteomes; UP000013520; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR PANTHER; PTHR32347; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR PANTHER; PTHR32347:SF23; UPF0194 MEMBRANE PROTEIN YBHG; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000013520};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..346
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 122..149
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 355 AA; 38981 MW; 63BFA5746AA0F89E CRC64;
MEALNKIDFK KVMVFILFMS IICIGILIFY RYFYLQKVIL DNERQSLTAT GTIEATTVLA
SFKIPGKLKN VLVDEGIKVE IEQEIASLED QEISSDLVAA QGAYDAAVAQ AQQASESVSL
TSEQVESTIN QLQAKLAQAE IGVKDAKLSY DRALSLFQSG AVPQKTLDDA TSAYNLAQSK
LHEARAGLEQ ALANKLNVSV AQSQYQAAQG SVKQASGAVQ KAEAYLKNTH LLSPISGYIT
KKYLQPGEML NAGTPVYEIT DLVHTYVNIY ISEKKIGRVH LNQEAEITVD AFPDRVFKGK
VVLINDAGEF AVQKAIDDQY EHDIRSFRVK IDVPNDDLAL KTGMTARVRI IEGGQ
//
