ID R4LWA2_MYCTX Unreviewed; 347 AA.
AC R4LWA2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=I917_07590 {ECO:0000313|EMBL:AGL22785.1};
OS Mycobacterium tuberculosis str. Haarlem/NITR202.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1304279 {ECO:0000313|EMBL:AGL22785.1, ECO:0000313|Proteomes:UP000013563};
RN [1] {ECO:0000313|EMBL:AGL22785.1, ECO:0000313|Proteomes:UP000013563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Haarlem/NITR202 {ECO:0000313|EMBL:AGL22785.1,
RC ECO:0000313|Proteomes:UP000013563};
RX PubMed=23788533;
RA Narayanan S., Deshpande U.;
RT "Whole-Genome Sequences of Four Clinical Isolates of Mycobacterium
RT tuberculosis from Tamil Nadu, South India.";
RL Genome Announc. 1:e00186-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; CP004886; AGL22785.1; -; Genomic_DNA.
DR KEGG; mtuh:I917_07590; -.
DR PATRIC; fig|1304279.3.peg.405; -.
DR HOGENOM; CLU_009834_22_1_11; -.
DR BioCyc; MTUB1304279:G13AB-1031-MONOMER; -.
DR Proteomes; UP000013563; Chromosome.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AGL22785.1}.
FT DOMAIN 16..72
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
FT DOMAIN 145..338
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
FT REGION 95..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 347 AA; 36920 MW; BFDDEA0F36A12E79 CRC64;
MTGESHEVLT NVEGGVGFVT LNRPKAINSL NQTMVDLLAT VLMSWEHEDA VHAVVLSGAG
ERXLCAGGDV DGRLPQCXQG RGRGAAVLAP RVSAQRPDRP XRQALRGVDG RHRNGRRRRR
QRTREHPGGY AXXLQGRDAR SGHRGVIPDV GGVYLLSRAP GALGLHAALT GAPFSGADAI
ALGFADHFVP HGDLDAFTQK IVTGGVESAL AAHAVEPPPS TLAAQRDWID ECYAGDSVAD
IVAALRKQGG EPAVNASDLI ASRSPIALSV TLQAVRRAAK LDTLEDVLIQ DYRVSSASLR
SHDLVEGIRA QLIDKDRNPN WSPATLDAIT AADIEAYFEP VDDDLSF
//
