ID R4M1H0_MYCTX Unreviewed; 178 AA.
AC R4M1H0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Replicative DNA helicase {ECO:0000313|EMBL:AGL21831.1};
GN ORFNames=I917_00365 {ECO:0000313|EMBL:AGL21831.1};
OS Mycobacterium tuberculosis str. Haarlem/NITR202.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1304279 {ECO:0000313|EMBL:AGL21831.1, ECO:0000313|Proteomes:UP000013563};
RN [1] {ECO:0000313|EMBL:AGL21831.1, ECO:0000313|Proteomes:UP000013563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Haarlem/NITR202 {ECO:0000313|EMBL:AGL21831.1,
RC ECO:0000313|Proteomes:UP000013563};
RX PubMed=23788533;
RA Narayanan S., Deshpande U.;
RT "Whole-Genome Sequences of Four Clinical Isolates of Mycobacterium
RT tuberculosis from Tamil Nadu, South India.";
RL Genome Announc. 1:e00186-13(2013).
CC -!- FUNCTION: Participates in initiation and elongation during chromosome
CC replication; it exhibits DNA-dependent ATPase activity.
CC {ECO:0000256|ARBA:ARBA00002835}.
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DR EMBL; CP004886; AGL21831.1; -; Genomic_DNA.
DR KEGG; mtuh:I917_00365; -.
DR PATRIC; fig|1304279.3.peg.1011; -.
DR HOGENOM; CLU_1509033_0_0_11; -.
DR BioCyc; MTUB1304279:G13AB-61-MONOMER; -.
DR Proteomes; UP000013563; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR InterPro; IPR016136; DNA_helicase_N/primase_C.
DR PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR Pfam; PF00772; DnaB; 1.
DR SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:AGL21831.1};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000313|EMBL:AGL21831.1};
KW Hydrolase {ECO:0000313|EMBL:AGL21831.1};
KW Nucleotide-binding {ECO:0000313|EMBL:AGL21831.1}.
FT DOMAIN 23..125
FT /note="DNA helicase DnaB-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00772"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 178 AA; 19024 MW; 78C4B99E09CCB24D CRC64;
MAVVDDLAPG MDSSPPSEDY GRQPPQDLAA EQSVLGGMLL SKDAIADVLE RLRPGDFXRP
AHQNVYDAIL DLYGRGEPAD AXTVAAELDR RGLLRRIGGA PYLHTLISTV PTAANAGYYA
SIVAEKALLR RLVEAGTRVV XYGXARXRRR GCGRGGRSRA GRNLRRRGSA AVGRLCGA
//
