ID R4M5F8_MYCTX Unreviewed; 859 AA.
AC R4M5F8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Polyketide synthase pks5 {ECO:0000313|EMBL:AGL23201.1};
GN ORFNames=I917_10810 {ECO:0000313|EMBL:AGL23201.1};
OS Mycobacterium tuberculosis str. Haarlem/NITR202.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1304279 {ECO:0000313|EMBL:AGL23201.1, ECO:0000313|Proteomes:UP000013563};
RN [1] {ECO:0000313|EMBL:AGL23201.1, ECO:0000313|Proteomes:UP000013563}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Haarlem/NITR202 {ECO:0000313|EMBL:AGL23201.1,
RC ECO:0000313|Proteomes:UP000013563};
RX PubMed=23788533;
RA Narayanan S., Deshpande U.;
RT "Whole-Genome Sequences of Four Clinical Isolates of Mycobacterium
RT tuberculosis from Tamil Nadu, South India.";
RL Genome Announc. 1:e00186-13(2013).
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DR EMBL; CP004886; AGL23201.1; -; Genomic_DNA.
DR KEGG; mtuh:I917_10810; -.
DR PATRIC; fig|1304279.3.peg.1299; -.
DR HOGENOM; CLU_000022_31_5_11; -.
DR BioCyc; MTUB1304279:G13AB-1451-MONOMER; -.
DR Proteomes; UP000013563; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044283; P:small molecule biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 776..852
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 859 AA; 92018 MW; D0C869151578E316 CRC64;
MSWPQRADHA AQAARLRDQL GTGGFTGVFV LTAPQTGDPD AESPVRGGEL VKHVVRIARE
IPEITAQEPR LYVLTHNAQA VLSGDRPNLE QGGMRGLLRV IGAEHPHLKA SYVDVDEQTG
AESVARQLLA ASGEDETAWR NDQWYTARLC PAPLRPEERQ TTVVDHAEAG MRLQIRTPGD
LQTLEFAAFD RVPPGPGEIE VAVTASSINF ADVLVTFGRY QTLDGRQPQL GTDFAGVVSA
VGPGVSELKV GDRVGGMSPN GCWATFVTCD ARLATRLPEG LTDAQAAAVT TASATAWYGL
QDLARIKAGD KVLIHSATGG VGQAAIAIAR AAGAQIYATA GNEKRRDLLR DMGIEHVYDS
RSVEFAEQIR RDTAGYGVDI VLNSVTGAAQ LAGLKLLALG GRFIEIGKRD IYSNTRLELL
PFRRNLAFYG LDLGLMSVSH PAAVRELLST VYRLTVEGVL PMPQSTHYPL AEAAXAIRVM
GAAEHTGKLI LDVPHAGRSS VVLPPEQARX FRSDGSYIIT GGLGGLGLFL AEKMANAGAG
RIVLSSRSQP SQKALETIEL VRAIGSDVVV ECGDIAQPDT ADRLVTAATA TGLPLRGVLH
AAAVVEDATL ANITDELIER DWAPKAYGAW QLHRATADQP LDWFCSFSSA AALVGSPGQG
AYAAANSWLD TFTHWRRAQD LPATSIAWGA WGQIGRAIAF AEQTGDAIAP EEGGXRRSQT
LLRHNRAYSG XAPVIGSPWL TAFAQHSPFA EKFQSLGQNR SGTSKFLAEL VDLPREEWPD
RLRXXLSKQV GLILRRTIDT DRLLSEYGLD SLSSQELRAR VXAETGIRIS ATEINTTVRG
LADLMCDKLA ADRDAPAPA
//
