ID R4SR17_9PSEU Unreviewed; 1105 AA.
AC R4SR17;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Penicillin acylase {ECO:0000313|EMBL:AGM02641.1};
GN ORFNames=AORI_0052 {ECO:0000313|EMBL:AGM02641.1};
OS Amycolatopsis keratiniphila.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
OX NCBI_TaxID=129921 {ECO:0000313|EMBL:AGM02641.1, ECO:0000313|Proteomes:UP000013968};
RN [1] {ECO:0000313|EMBL:AGM02641.1, ECO:0000313|Proteomes:UP000013968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HCCB10007 {ECO:0000313|EMBL:AGM02641.1,
RC ECO:0000313|Proteomes:UP000013968};
RX PubMed=23627759; DOI=10.1186/1471-2164-14-289;
RA Tang B., Wang Q., Yang M., Xie F., Zhu Y., Zhuo Y., Wang S., Gao H.,
RA Ding X., Zhang L., Zhao G., Zheng H.;
RT "ContigScape: a Cytoscape plugin facilitating microbial genome gap
RT closing.";
RL BMC Genomics 14:289-289(2013).
CC -!- SIMILARITY: Belongs to the peptidase S45 family.
CC {ECO:0000256|ARBA:ARBA00006586}.
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DR EMBL; CP003410; AGM02641.1; -; Genomic_DNA.
DR AlphaFoldDB; R4SR17; -.
DR MEROPS; S45.001; -.
DR KEGG; aoi:AORI_0052; -.
DR PATRIC; fig|1156913.3.peg.53; -.
DR HOGENOM; CLU_311672_0_0_11; -.
DR Proteomes; UP000013968; Chromosome.
DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 2.
DR Gene3D; 1.10.439.10; Penicillin Amidohydrolase, domain 1; 1.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR023343; Penicillin_amidase_dom1.
DR InterPro; IPR002692; S45.
DR PANTHER; PTHR34218:SF4; ACYL-HOMOSERINE LACTONE ACYLASE QUIP; 1.
DR PANTHER; PTHR34218; PEPTIDASE S45 PENICILLIN AMIDASE; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF01804; Penicil_amidase; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR PROSITE; PS50022; FA58C_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000013968};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1105
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004370588"
FT DOMAIN 931..1022
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT REGION 322..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1040
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1105 AA; 117582 MW; 9674FAFF92DE580F CRC64;
MTTLAGLTLV AGTVPALQAN AAEAPQNSVV AAALDDYCGG QCGDILPPGT KGNATLAEIL
AHKAFGTRPA HSADQLGKYA SLADGYKTLT TDKINQFFND ASFGVPSGQV ESTIKPRSDV
TITRDKATGV PRIVGTTRPG TMYGAGYAAA QDRLWLMDIM RRVGRGQLTS FAGGAQGNRE
LEQSFFSSAP YTEQELQKQI DNAAASGPRG AQGKADAEAY VQGVNKYISD AHGGRYFPGE
YVLTGHVDAI TNAGTIEPFK LTDLVVLAAV VGAQFGAGGG GEVQNAIAKM AMQEKYGLEQ
GDKVWRSLRS EDDPETVKTL HNGQTFDYGK APSNPQGAAM PDKGSVTGQQ LVFDPTGSAG
TATPAKVDVP APEDQKAVRG IFDDGVLPGN LLSEKHGMSN ALVVSGAKTA SGHPVAVFGP
QAGYFAPQLL MLQEIQGPGI SARGASFAGI SMYVLLGRGK DYSWSATSAS QDIIDTYAVE
LCEQNGSAPT KNSNFYRFRG QCLPFEIVER KNAWKPTVAD GTAEGSYTLR SFRTKYGPVT
SRALVGGKPV AYASLRSTFQ HEIDTIIGFQ KFNDPDAIKS AQDFQAAAAD VNQTYNWFYA
DSRDVAYFNS GSNPVRNPNV DPAMPVKADA GFDWQGWNPD GNLANYTPSS QHPQSINQDY
YISWNNAQAS GYAASGADKS SVHRGDLIDA RVKKMVSSGT KVTRVNLTQA MEEAALADLR
AEKVLPELFK VIDKAPVTGP AADAVAKLKT WLAAGGLRSE TAPGSKVYAN ADAIRIMDAW
WPLLVNAQFK PGMGDAAYGA MVGVLKINES PSGWQNEVPG KHVGQGHAGS SYQSGWWGYV
HKDIRSVLGQ NVAGPLAVKY CGGGDVTACR QVLLDSLTQA AAQPANTVYP GDGDCAAGDQ
WCADTIIHRA LGGITQDKMS TQNRPTFQQV VEFPAKRGDN IANLATGRSV SASSHETGWY
NSPPSNAIDV DLSTRWASDW SDNQSITVDL GSVQRVSRVV LRWESAYGKG VQGAGLVRRH
ELAGRGVHSG RKRRNGQRRV RGGGRALCPD GRCPARDEVR LLPLRVRGVR PLTRARFTVA
GWTRTTGHPA PSPSPPDVRR GPASR
//
