ID R4SVG2_9PSEU Unreviewed; 486 AA.
AC R4SVG2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=GntR family transcriptional regulator / MocR family aminotransferase {ECO:0000313|EMBL:AGM07344.1};
GN ORFNames=AORI_4760 {ECO:0000313|EMBL:AGM07344.1};
OS Amycolatopsis keratiniphila.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
OX NCBI_TaxID=129921 {ECO:0000313|EMBL:AGM07344.1, ECO:0000313|Proteomes:UP000013968};
RN [1] {ECO:0000313|EMBL:AGM07344.1, ECO:0000313|Proteomes:UP000013968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HCCB10007 {ECO:0000313|EMBL:AGM07344.1,
RC ECO:0000313|Proteomes:UP000013968};
RX PubMed=23627759; DOI=10.1186/1471-2164-14-289;
RA Tang B., Wang Q., Yang M., Xie F., Zhu Y., Zhuo Y., Wang S., Gao H.,
RA Ding X., Zhang L., Zhao G., Zheng H.;
RT "ContigScape: a Cytoscape plugin facilitating microbial genome gap
RT closing.";
RL BMC Genomics 14:289-289(2013).
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; CP003410; AGM07344.1; -; Genomic_DNA.
DR RefSeq; WP_016335092.1; NC_021252.1.
DR AlphaFoldDB; R4SVG2; -.
DR KEGG; aoi:AORI_4760; -.
DR PATRIC; fig|1156913.3.peg.4838; -.
DR HOGENOM; CLU_017584_0_1_11; -.
DR Proteomes; UP000013968; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:AGM07344.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000013968};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:AGM07344.1}.
FT DOMAIN 14..82
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 486 AA; 54136 MW; 7D81F08BB8B9F9CA CRC64;
MPRTLIEIDR TSAEPLYRQV RRAIEHGIAI GTFDPAHRLP SSRELAAELG VSRNTINLAY
QELVAEGFVE SRERSGLFIN AEMRPHCAVQ ERGTSPAIDW SARVRRYPDA GVPHIEKRPD
WHTYPYPFLA GQVDVTAFPA RSWTRCLRDA LYRPHVFPSL QDSVGSDDPM LVDLICRQLL
TARGIEADPS EVLITVGSQQ GLDLLGRALL GPDSVVAMEN PGYLDARHIF LRTGAGLRGV
DVDQSGLRPP DTLDGVDLLY LTPSHHHPTN ATLSIGRRRR LLSLAASAGT VLVEDDYDSE
FRYHGSPTPA LKALDGTGDA IYLGTFSKFL SPGLRLGYLV GPRELVRELR EIRRYVLRHP
PGHLQRALAL LIDSGEYHRS LRRYRTKLMR KWEATCAAVT EHLPWTQTAY PPGGVSLWMT
GPPELDCRAL IERAERDGVL IEPGDIFFVG DDPPKNHFRI GFAAVPLRDI DPGIRLLGQA
CRDLIA
//
