ID R4SWS5_9PSEU Unreviewed; 801 AA.
AC R4SWS5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:AGM04606.1};
GN Name=comE {ECO:0000313|EMBL:AGM04606.1};
GN ORFNames=AORI_2018 {ECO:0000313|EMBL:AGM04606.1};
OS Amycolatopsis keratiniphila.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
OX NCBI_TaxID=129921 {ECO:0000313|EMBL:AGM04606.1, ECO:0000313|Proteomes:UP000013968};
RN [1] {ECO:0000313|EMBL:AGM04606.1, ECO:0000313|Proteomes:UP000013968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HCCB10007 {ECO:0000313|EMBL:AGM04606.1,
RC ECO:0000313|Proteomes:UP000013968};
RX PubMed=23627759; DOI=10.1186/1471-2164-14-289;
RA Tang B., Wang Q., Yang M., Xie F., Zhu Y., Zhuo Y., Wang S., Gao H.,
RA Ding X., Zhang L., Zhao G., Zheng H.;
RT "ContigScape: a Cytoscape plugin facilitating microbial genome gap
RT closing.";
RL BMC Genomics 14:289-289(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003410; AGM04606.1; -; Genomic_DNA.
DR RefSeq; WP_016332403.1; NC_021252.1.
DR AlphaFoldDB; R4SWS5; -.
DR KEGG; aoi:AORI_2018; -.
DR PATRIC; fig|1156913.3.peg.2067; -.
DR HOGENOM; CLU_010363_4_0_11; -.
DR Proteomes; UP000013968; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000013968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 547..748
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 801 AA; 81836 MW; 0059BAA1B8DC92D5 CRC64;
MNPSADPSEV DTASWRGQDL RLLPAAATAW LGTLSGLLAG WWITMLCGAA AVVLAIIAGV
RARRTASRWV AGLGALAVLG VLTAGPVALR IRAAEHDDLR AAAARGSDAT TTVVVTERPR
PVRGAGYADR RAGTRLMVIA ATVGTAVAGE RVVDSAGRIL LLAPAEGWTD LLPGQQVTAS
GRLAPAKGAE LTVAVLSVRG PPSAVAPAPW WQRAAESLRT GLRELCAVLP EEEAGLVPGL
VVGDTSTLSP RVEHEFTDSG MSHLMAVSGG NVAIVCGSIL LLLRVLRVGP RTSAAAAAVG
LAGFVVLAGP APSVLRAGVM GAVGLLALAL GRRGSALPAL AFAVAGLVVA DPAMAADFGF
ALSVLATAGL VLLAPRWADW LVGRGVPAGY AEGLAIPLAA FVMTAPVIAG MAGSVSLVSV
LTNVLAAPVV APATVFGVLA TAVGPWWPSA GRLLVRLTEP EASWLITVAR HGARAPGAVV
DWPDGWWGGL LAAGLLSVLL VVVRLRHGRI LLAVALATGL VVFVPVRVLA PAWPPSAWNA
VACDVGQGDA VALATGEPGR AVLVDTGPEP GPVDECLSRL GVDRVPLIVL SHLHADHIGG
LGSVFEGRSV GAVAVGPGRA PAWAWQQVAD ETARRGIPLL ELEIGQRLEW QALSLDVLGP
RYVTRRSVRE QDGTVINNGS VVLRAGTPAG RLLLTGDIEL AAQADLMAEG ADLRAEILKV
PHHGSRYTAP DFLNAVAPRA ALVSVGAGNT YGHPNKSTLD NLVAVGASVA RTDTDGDTAV
IADGRGLALV RRGEPRGPPR S
//
