ID R4T0K6_9PSEU Unreviewed; 627 AA.
AC R4T0K6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Peptidase M48 Ste24p {ECO:0000313|EMBL:AGM04537.1};
GN ORFNames=AORI_1949 {ECO:0000313|EMBL:AGM04537.1};
OS Amycolatopsis keratiniphila.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
OX NCBI_TaxID=129921 {ECO:0000313|EMBL:AGM04537.1, ECO:0000313|Proteomes:UP000013968};
RN [1] {ECO:0000313|EMBL:AGM04537.1, ECO:0000313|Proteomes:UP000013968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HCCB10007 {ECO:0000313|EMBL:AGM04537.1,
RC ECO:0000313|Proteomes:UP000013968};
RX PubMed=23627759; DOI=10.1186/1471-2164-14-289;
RA Tang B., Wang Q., Yang M., Xie F., Zhu Y., Zhuo Y., Wang S., Gao H.,
RA Ding X., Zhang L., Zhao G., Zheng H.;
RT "ContigScape: a Cytoscape plugin facilitating microbial genome gap
RT closing.";
RL BMC Genomics 14:289-289(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003410; AGM04537.1; -; Genomic_DNA.
DR AlphaFoldDB; R4T0K6; -.
DR KEGG; aoi:AORI_1949; -.
DR PATRIC; fig|1156913.3.peg.1996; -.
DR HOGENOM; CLU_017915_0_0_11; -.
DR Proteomes; UP000013968; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07328; M48_Ste24p_like; 1.
DR Gene3D; 3.30.2010.10; Metalloproteases ('zincins'), catalytic domain; 1.
DR InterPro; IPR001915; Peptidase_M48.
DR PANTHER; PTHR43221; PROTEASE HTPX; 1.
DR PANTHER; PTHR43221:SF1; PROTEASE HTPX; 1.
DR Pfam; PF01435; Peptidase_M48; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000013968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 82..303
FT /note="Peptidase M48"
FT /evidence="ECO:0000259|Pfam:PF01435"
SQ SEQUENCE 627 AA; 67767 MW; 2E4F694ECB0DC970 CRC64;
MQARGRAVLA TLLLVAFPVV VVAVGVASVL AGLRIQGKIG TYVMLGGLAI MVALGFGLMS
ALRARRPPIE GPRLDREAHP ALWEMIDDLA ALVKTRPPDE IVLIGEINAA VSEDARFLGL
RPGRRTMLIG LPLLAAMSVS ELRSVLAHEL GHYSGGHTRL LALTYRGTQT LAFTVDRLDG
GPARALLSAY SKLYLLVARS ANRRQELQAD EASVLAAGSR TAAAALRKVA TLSPLWKDYA
ERYLSLGAAA RRTPPVLLGF RSYLNHPVQR DWMAEYAEDI IDGEELSKYD SHPPTKRRIA
ALVGVPDNPV KPDARPGWSL LGAPKIDVPE AELDVLIRDV GPRADWDEVV KRAGRASVAE
GARLLTAAGI ESRLAPRGTI GEVVRVLRDG DADALAKPLR APSREEGLDL LTELFADTVT
AAMIDNGVAA HRLNWGGGWE LCLGDGEPFD VTELVGAAVR SPRAVDELVH NLQLLSVPAA
YFCKQEPQPE PDPAEARMLG MFTALKAKRK LYDLIVCDTE VVLLPLARSV LLRRGLAGLI
GARGVSDRKR IRKLRERGLD DLRAEPGARR IPFPDIVAGG FPRRKLTTYL TLELSDGETL
ELAITGNTED FGAAHDELTA FFASLKA
//
